a role for phosphatidic acid in the formation of “supersized” lipid droplets磷脂酸的作用u201c超大型u201d脂滴的形成.pdfVIP

A Role for Phosphatidic Acid in the Formation of ‘‘Supersized’’ Lipid Droplets 1. 2,3. 1. 4 5 Weihua Fei , Guanghou Shui , Yuxi Zhang , Natalie Krahmer , Charles Ferguson , Tamar S. 1 1 1 1 6 7 5 Kapterian , Ruby C. Lin , Ian W. Dawes , Andrew J. Brown , Peng Li , Xun Huang , Robert G. Parton , 2,3 4 1 Markus R. Wenk , Tobias C. Walther , Hongyuan Yang * 1 School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia, 2 Department of Biochemistry, National University of Singapore, Singapore, Singapore, 3 Department of Biological Sciences, National University of Singapore, Singapore, Singapore, 4 Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut, United States of America, 5 Institute for Molecular Bioscience and Centre for Microscopy and Microanalysis, University of Queensland, Brisbane, Australia, 6 Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, China, 7 Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China Abstract Lipid droplets (LDs) are important cellular organelles that govern the storage and turnover of lipids. Little is known about how the size of LDs is controlled, although LDs of diverse sizes have been observed in different tissues and under different (patho)physiological conditions. Recent studies have indicated that the size of LDs may influence adipogenesis, the rate of lipolysis