有哪些信誉好的足球投注网站a plasma biomarker signature of immune activation in hiv patients on antiretroviral therapy等离子体生物标志物签名的免疫激活在抗逆转录病毒治疗的艾滋病患者.pdfVIP
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a plasma biomarker signature of immune activation in hiv patients on antiretroviral therapy等离子体生物标志物签名的免疫激活在抗逆转录病毒治疗的艾滋病患者
A Plasma Biomarker Signature of Immune Activation in HIV Patients on Antiretroviral Therapy 1,2 1 1,2 3 4 4 Anupa Kamat , Vikas Misra , Edana Cassol , Petronela Ancuta , Zhenyu Yan , Cheng Li , Susan Morgello5, Dana Gabuzda1,2* 1 Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America, 2 Harvard Medical School, Boston, ´ ´ Massachusetts, United States of America, 3 Department of Microbiology and Immunology, Faculty of Medicine, CHUM-Research Center, Universite de Montreal, Montreal, Canada, 4 Department of Biostatistics, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America, 5 Mount Sinai Medical Center, New York, United States of America Abstract Background: Immune activation is a strong predictor of disease progression in HIV infection. Combinatorial plasma biomarker signatures that represent surrogate markers of immune activation in both viremic and aviremic HIV patients on combination antiretroviral therapy (cART) have not been defined. Here, we identify a plasma inflammatory biomarker signature that distinguishes between both viremic and aviremic HIV patients on cART and healthy controls and examine relationships of this signature to markers of disease progression. Methods: Multiplex profiling and ELISA were used to detect 15 cytokines/chemokines, soluble IL-2R (sIL-2R), and soluble CD14 (sCD14) in plasma from 57 HIV patients with CD4 nadir ,300 cells/ml and 29 healthy controls. Supervised
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