a model of brain circulation and metabolism nirs signal changes during physiological challenges脑血液循环和新陈代谢的nirs模型信号变化的生理挑战.pdfVIP

A Model of Brain Circulation and Metabolism: NIRS Signal Changes during Physiological Challenges 1 2 2 1 1 Murad Banaji *, Alfred Mallet , Clare E. Elwell , Peter Nicholls , Chris E. Cooper 1 Department of Biological Sciences, University of Essex, Colchester, United Kingdom, 2 Department of Medical Physics and Bioengineering, University College London, London, United Kingdom Abstract We construct a model of brain circulation and energy metabolism. The model is designed to explain experimental data and predict the response of the circulation and metabolism to a variety of stimuli, in particular, changes in arterial blood pressure, CO2 levels, O2 levels, and functional activation. Significant model outputs are predictions about blood flow, metabolic rate, and quantities measurable noninvasively using near-infrared spectroscopy (NIRS), including cerebral blood volume and oxygenation and the redox state of the CuA centre in cytochrome c oxidase. These quantities are now frequently measured in clinical settings; however the relationship between the measurements and the underlying physiological events is in general complex. We anticipate that the model will play an important role in helping to understand the NIRS signals, in particular, the cytochrome signal, which has been hard to interpret. A range of model simulations are presented, and model outputs are compared to published data obtained from both in vivo and in vitro settings. The comparisons are encouraging, showing that the model is able to reproduce observed behaviour in response to various stimuli. Citation: Banaji M, Mallet A, Elwell C