有哪些信誉好的足球投注网站a local role for the small ribosomal subunit primary binder rps5 in final 18s rrna processing in yeast当地的角色小核糖体亚基主要粘合剂rps5最后18 s rrna处理酵母.pdfVIP
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a local role for the small ribosomal subunit primary binder rps5 in final 18s rrna processing in yeast当地的角色小核糖体亚基主要粘合剂rps5最后18 s rrna处理酵母
A Local Role for the Small Ribosomal Subunit Primary Binder rpS5 in Final 18S rRNA Processing in Yeast ¨ Andreas Neueder, Steffen Jakob, Gisela Poll, Jan Linnemann, Rainer Deutzmann, Herbert Tschochner*, Philipp Milkereit* ¨ Institut fur Biochemie, Genetik und Mikrobiologie, University of Regensburg, Regensburg, Germany Abstract In vivo depletion of the yeast small ribosomal subunit (SSU) protein S5 (rpS5) leads to nuclear degradation of nascent SSUs and to a perturbed global assembly state of the SSU head domain. Here, we report that rpS5 plays an additional local role at the head/platform interface in efficient SSU maturation. We find that yeast small ribosomal subunits which incorporated an rpS5 variant lacking the seven C-terminal amino acids have a largely assembled head domain and are exported to the cytoplasm. On the other hand, 39 processing of 18S rRNA precursors is inhibited in these ribosomal particles, although they associate with the putative endonuclease Nob1p and other late acting 40S biogenesis factors. We suggest that the SSU head component rpS5 and platform components as rpS14 are crucial constituents of a highly defined spatial arrangement in the head – platform interface of nascent SSUs, which is required for efficient processing of the therein predicted SSU rRNA 39 end. Positioning of rpS5 in nascent SSUs, including its relative orientation towards platform components in the head- platform cleft, will depend on the general assembly and folding state of the head domain. Therefore, the suggested model can explain 18S precursor rRNA 39 processing phenotypes observed in many eukaryotic SSU head assembly mutants. ¨ Citation: Neueder A, Jakob S, Poll G, Linnemann J, Deutzmann R, et al. (2010) A Local Role for the Small Ribosomal Subunit Prima
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