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a characterization of the oral microbiome in allogeneic stem cell transplant patients口腔微生物的特性在同种异体干细胞移植的病人
A Characterization of the Oral Microbiome in Allogeneic Stem Cell Transplant Patients 1 2¤a 1¤b 3 3 4,5 Nancy J. Ames *, Pawel Sulima , Thoi Ngo , Jennifer Barb , Peter J. Munson , Bruce J. Paster , Thomas C. Hart2¤c 1 Clinical Center, Nursing and Patient Care Services, National Institutes of Health, Bethesda, Maryland, United States of America, 2 Human Craniofacial Genetic Section, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, Bethesda, Maryland, United States of America, 3 Mathematical and Statistical Computing Laboratory, Center for Information Technology, National Institutes of Health, Bethesda, Maryland, United States of America, 4 Department of Microbiology, Forsyth Institute, Cambridge, Massachusetts, United States of America, 5 Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, United States of America Abstract Background: The mouth is a complex biological structure inhabited by diverse bacterial communities. The purpose of this study is to describe the effects of allogeneic stem cell transplantation on the oral microbiota and to examine differences among those patients who acquired respiratory complications after transplantation. Methodology/Principal Findings: All patients were consented at the National Institutes of Health, Clinical Center. Bacterial DNA was analyzed from patients’ oral specimens using the Human Oral Microbe Identification Microarray. The specimens were collected from four oral sites in 45 allogeneic transplantation patients. Specimens were collected at baseline prior to transplantation, after transplantation at the nadir of the
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