a blueprint for real-time functional mapping via human intracranial recordings实时的蓝图通过人类颅内录音功能映射.pdfVIP

A Blueprint for Real-Time Functional Mapping via Human Intracranial Recordings 1,2 1,2,3 1,2 4 5 1 Jean-Philippe Lachaux *, Karim Jerbi , Olivier Bertrand , Lorella Minotti , Dominique Hoffmann , Benjamin Schoendorff , Philippe Kahane4 ´ ´ ´ 1 INSERM, U821, Lyon, F-69500, France, 2 Institut Federatif des Neurosciences, Lyon, F-69000, France; Universite Lyon 1, Lyon, F-69000, France, ` 3 Laboratoire de Physiologie de la Perception et de l’Action, CNRS, College de France, Paris, France, 4 Department of Neurology and INSERM U704, Grenoble Hospital, Grenoble, France, 5 Department of Neurosurgery and INSERM U318, Grenoble Hospital, Grenoble, France Background. The surgical treatment of patients with intractable epilepsy is preceded by a pre-surgical evaluation period during which intracranial EEG recordings are performed to identify the epileptogenic network and provide a functional map of eloquent cerebral areas that need to be spared to minimize the risk of post-operative deficits. A growing body of research based on such invasive recordings indicates that cortical oscillations at various frequencies, especially in the gamma range (40 to 150 Hz), can provide efficient markers of task-related neural network activity. Principal Findings. Here we introduce a novel real-time investigation framework for mapping human brain functions based on online visualization of the spectral power of the ongoing intracranial activity. The results obtained with the first two implanted epilepsy patients who used the proposed online system illu