a half-century of inspiration an interview with hamilton smith半个世纪的灵感采访汉密尔顿·史密斯.pdfVIP

Interview A Half-Century of Inspiration: An Interview with Hamilton Smith Jane Gitschier* Department of Medicine and Pediatrics, University of California San Francisco, San Francisco, California, United States of America In 1962, Hamilton Smith abandoned a Gitschier: Let’s start with how you got Gitschier: How was that? career in medicine to follow his passion for involved in basic research after going to Smith: I had one afternoon a week free. the emerging field of molecular biology; medical school. And I could go up to the Naval Hospital. So within six years, he had made the discovery Smith: After my internship [at Barnes I went up to the endocrine clinic, and of a lifetime. As a new Johns Hopkins Hospital in Saint Louis], the plan was just worked there on, I think, Wednesday faculty member, Smith, together with his to go on with the system—residency. At afternoons. And saw people with various first graduate student, Kent Wilcox, geared that time there was no draft, but there was disorders, among them, some genetic-type up to study recombination in vitro but a doctors’ draft. There weren’t enough defects. And I started reading up on that. instead discovered the restriction enzyme doctors volunteering to serve, so by lottery Somebody found that if you put the cells on ‘‘R’’ in Haemophilus influenzae. By cobbling they would select one out of every ten a slide and then mashed the coverslip with together crude techniques, Smith, along physicians for a two-year period. And my your thumb, the cells would spread out and with Wilcox and later Tom Kelly, showed number came up. I was just married, so w