去头屑化妆品功效评价方法探析.docVIP

去头屑化妆品功效评价方法探析[摘要]目的:探讨去头屑化妆品的功效评价方法。方法:采用随机双盲自身对照研究,通过研究者评估、受试者自评及马拉色菌定量培养方法,比较试验前后两侧头皮的临床评分及马拉色菌量的变化来评价去头屑香波的功效,同时进行安全性评估。结果:本试验方法显示试验香波(含去屑功效成分)在降低头皮多项临床评分及马拉色菌量方面均明显优于对照香波。试验香波具有良好的去屑、止痒及去除油脂功效,且安全性较好。结论:本评价方法能对去屑香波的功效及安全性作出科学合理的评价。 [关键词]化妆品;去屑功效;马拉色菌 [中图分类号]TQ658.3+3[文献标识码]A [文章编号]1008-6455(2010)01-0072-03 Study of efficacy evaluation method of anti-dandruff cosmetics XIE Xiao-yuan,WANG Ran,LAI Wei,WAN Miao-jian,GONG Zi-jian, LU Chun,YI Jin-ling (Department of Dermatology,the Third Affiliated Hospital of Sun Yat-sen University,Guangzhou510630 Guangdong,China ) Abstract: ObjectiveTo investigate the efficacy evaluation method of anti-dandruff cosmetics. Methods We adopted double-blinded and self-controlled test under random conditions. All the subjects randomly applied two different shampoos on their left and right scalps respectively. Through investigators’ and subjects’ self assessments to compare the differences of the test shampoo and the controlled shampoo in improving the clinical assessment scores, at the same time malassezia quantitative culture was conducted to compare the changes of malassesia load on both sides of scalps. ResultsBy this method, we found that the test shampoo demonstrated more excellent superiority in both decreasing various clinical assessment scores and malassezia load compared to the controlled shampoo. The test shampoo presents a good ability in clearing off dandruff, relieving itching and excess oil on the scalp.ConclutionsThis evaluation method is regarded as a scientific and reasonable route for the efficacy evaluation of the anti-dandruff cosmetics. Key words:cosmetics;anti-dandruff efficacy; malassezia 按照世界卫生组织定义的身体健康标准,“头发有弹性,有自然光泽,没有头屑”便是其中很重要的一条标准。而目前,头屑问题已成为仅次于脱发而困扰消费者的第二大头发健康问题,长期应用去头屑化妆品(洗发香波)一直以来都是广大头皮屑患者的最主要治疗选择。随着去头屑香波的日益增多,针对去头屑香波的功效评价方法愈发显得重要,而目前国内外尚缺乏评价此类香波的统一标准和方法,笔者采用研究者评估、受试者自评及马拉色菌定量培养相结合的方法对某品牌去屑香波的功效进行了临床评估,以期探讨适合于我国国情的简便有效的功效评估方法,现将结果报道如下。 1研究对象和方法 1.1研究对象 1.1.1纳入标准:受试者具有明显头皮屑