pg与氯前列醇合用（PG is compatible with the use of alcohol）.docVIP

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pg与氯前列醇合用（PG is compatible with the use of alcohol）.doc

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pg与氯前列醇合用（PG is compatible with the use of alcohol）

pg与氯前列醇合用（PG is compatible with the use of alcohol） Application of prostaglandin F2 alpha cloprostenol and its analogues in animals reproduction (2009-08-08 23:19:10) reprint labels: Classification: expert lecture topics The application of prostaglandin F2 alpha and its analogues in the breeding of domestic animals Prostaglandins were first discovered in human semen by the American obstetricians and obstetricians Kurzrok and Lieb, and were originally thought to have only the presence of this substance in the acid esters of the prostate gland, which is called prostaglandins. In fact, many tissues can be produced in animals. So far, more than 20 prostaglandins have been found. In accordance with the substitution of five carbon ring, which can be divided into A, B, C, D, E, F, G, H, I type, each type with side chain containing double chain number is divided into 3 categories (such as PGE1, PGE2, PGE3). (CLO) is a derivative of prostaglandin F2 alpha, which has high solubility in corpus luteum. 1 main biological functions and mechanisms Existing studies have shown that the biological effects of the enolase are similar to that of PGF2 alpha, but its half-life is longer and the activity of dissolving corpus luteum is higher. 1.1 dissolution of progesterone: the mechanism of action is: (1) PGF2 alpha inhibits progesterone synthesis and accelerates progesterone degradation. PGF2 alpha inhibition of cholesterol from transport to the inner mitochondrial membrane, and cause the decline of living cells in P450 side chain cleavage enzyme activity induced by oxygen free radicals or intermediates, thereby inhibiting progesterone synthesis; LH by accelerating the 20 hydroxylase reaction can promote progesterone synthesis; PGF2 alpha antigonadotropin such as, cause a reduction in the HCG receptors, binding capacity decreased, inhibiting cAMP response to gonadotropin stimulation, prevent cAPM on steroidogenesis. (2) PGF2 alpha causes the decrease of the membrane fluidity of the corpu