at1受体（AT1 receptor）.docVIP

at1受体（AT1 receptor） [Key words] hypertension At present, AT1 receptor autoantibodies in hypertension and pregnancy induced hypertension syndrome with high detection rate of patients with high serum, and that kind of excited effect of the antibody has similar angiotensin II, which binds to the AT1 receptor to produce excitatory effects, such as cell proliferation, vascular wall thickening and target organ reconstruction. Therefore, angiotensin II receptor antagonist by blocking AT1 receptor selectivity, which play a more obvious effect than ACEI. This paper reviews the recent related research results are introduced. 1 the distribution of AT1 receptor and its physiological function The AT1 receptor is mainly distributed in the human kidney, heart and vascular smooth muscle cells, adrenal cortex, brain, placenta and platelet. Animal experiments showed that different developmental stages of AT1 receptor distribution in different tissues or the same tissue is often different, the changes in the distribution and quantity of most regions of the brain in adult and juvenile or embryos had little difference, but the expression is different in different parts of the brain. Including its main physiological role: force growth and positive inotropic effect of stimulating the myocardial tissue cells; stimulates vascular smooth muscle cell proliferation and contraction of vascular smooth muscle; sympathetic nerve stimulation increased catecholamine release; stimulation of antidiuretic hormone and aldosterone secretion, control of water intake and urinary sodium excretion, which are related with elevated blood pressure [1]. The detection and biological effects of AT1 2 receptor autoantibodies Detection of 2.1 autoantibodies With the mutual penetration of the development of immunology and interdisciplinary, the immune system plays a more and more important role in the pathogenesis of hypertension. As early as 1992 it was suggested that the disorder of immune system in the development