多西他赛联合顺铂、5一Fu及亚叶酸钙治疗.PDFVIP

维普资讯 ’ ·590 · 肿瘤防治研究2008年第35卷第8期 ● 临床应用 多西他赛联合顺铂、5一Fu及亚叶酸钙治疗 晚期 胃癌 李 文，季德林，林华明 EffectsofDoeetaxel，CisplatinFluorouracilandCalcium FolinateinTreatmentofPatients withAdvancedStomachCancer LIWen，JIDe-lin，LIN Hua-ming DepartmentofOncology，People’SHospitalofMaomingCity，Maoming525000，China Abstract：Objective Toevaluatetheefficacyandtoxicityofthecombinationofdocetaxel，5-fluorouracil (5一Fu)andcalcium folinate(CF)inthetreatmentofpatientswithadvancedstomachcancer．Methods GroupA：The52patientswithadvancedstomachcancerreceivedDocetaxel75mg／m2iv，and5-Fu500 rag／m2dl～5iv，CF200mg／m2dl～5iv．Cisplatin (DDP)20mg／m dl～5，Acycleis3weeks．Group B：47patientsreceivedEPI35rag／m2，DDP，CF250mg／m2and5-Fu425nag／m2．Acycleis1weeksand 8cyclesisacourseoftreatment．Results TheoverallresponserateofGroupA was59．6 andtheover— allresponseofthecontrolofGroupBwas46．8 ．Theprogressionfreemediandurationofresponsive patientswas7．8monthsinGroupA and6．0monthsinGroupB-I—and2一yaersurvivalrateinGroupA was51 and19 ，nadinGroupBwere47％and9 ．Therewasnoobviousdifferencebetweenoverall responseratesand1-yaersurvivalrateoftwogroups(P0．05)．Theprogressionfreemde ianduration ofresponsivepatientsnad2-yearsurvivalrateweresignificantly differencebetween two groups(P 0．O5)．Themajorsideeffectsincludephlebitisandperipheralneuritiscanbeacceptedbymostofthepa— tients．Condusion CombinationofDocetaxel，CFand 5一Fuisaneffectiveregimeninthetraetmentofpa- tientswithadvancedstomachcancer． KeyWOldS：Stomachneoplasms；Docetaxel；Fluorouracil；Calcium folinate；Cisplatin 摘 要：目的 研究多西他赛联合顺铂、5-Fu及亚叶酸钙治疗晚期 胃癌的临床疗效。方法 试验组 52 例化疗方案：多西他赛 75nag／m2dl，5-Fu500mg／m2dl～5，亚叶酸钙 200mg／m2dl～5，顺铂 20mg／ m2dl～5，3周重复；对照组47例治疗用表阿霉素(EPI)35mg／m ，静脉推注，顺铂40mg／m2，亚叶酸 钙250mg／m2，5-Fu425mg／m2，静脉滴注，1次／周，连用8周评定疗效。结果 试验组有效率为