国外部分公司脂质体药物研发现状（Status quo of liposome drug development in some foreign companies）.docVIP

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2017-08-16 发布于河南
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国外部分公司脂质体药物研发现状（Status quo of liposome drug development in some foreign companies）.doc

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国外部分公司脂质体药物研发现状（Status quo of liposome drug development in some foreign companies）

国外部分公司脂质体药物研发现状（Status quo of liposome drug development in some foreign companies） Li Chunlei, Deng Yingjie (Shenyang Pharmaceutical University School of medicine, Liaoning Shenyang 110016) Abstract: Objective To introduce the development status of foreign liposomes. Methods liposome liposome technology platform for the development of 14 foreign companies and developing. Results and conclusion at present, there are mainly 3 kinds of liposomal drugs are being developed: \ vaccine and nucleic acid drugs of chemotherapy drugs. And foreign countries engaged in liposome drug development company has its own patented technology. Keywords: Pharmacy; research progress; review; liposome CLC number: R94 document code: A Since 1965, Bangham et al found liposome, nearly 40 years have passed. In the past 40 years, through continuous efforts of many research personnel, liposome domain appeared many milepost type, such as: pH gradient method, long circulating liposome preparation and active targeting liposomes of the invention. As an advanced drug delivery system, liposome has the advantage of being more recognized (the drug is a broad concept, including both chemical drugs, including proteins and nucleic acid drugs). The author will briefly introduce the development status of foreign liposomes. The so-called liposomes, refers to liposomes as the carrier of the treatment or prevention of drug. As in other countries, the new drug development work done mainly by the pharmaceutical company, so to introduce foreign countries engaged in liposome drug development company, liposome of new technologies and the development of them by the. 1 ALZA ALZA is a specialized in drug delivery system (drug delivery systems, DDSs [1,2]) development company. It is the main technology platform stealth liposome (STEALTH. liposomes, is in fact long circulating liposomes) technology. As everyone knows, although improve drug efficacy of traditional liposomes can reduce adverse drug reactions in vivo, but th