关注抗革兰阳性菌药物的特点（Pay attention to the characteristics of gram positive bacteria）.docVIP

关注抗革兰阳性菌药物的特点（Pay attention to the characteristics of gram positive bacteria） Gram positive bacteria can be divided into broad-spectrum antibiotics and narrow spectrum positive bacteria. The clinical isolates showed obvious resistance to broad-spectrum antibiotics, but some of them still had antibacterial effects on individual bacteria. Narrow spectrum of gram positive bacteria drug varieties have been increasing, but each product has its own characteristics. According to the Ministry of health related drug regulations, most of the narrow spectrum of anti gram positive bacteria drugs belong to special categories, must strictly enforce the regulations, especially the abuse of new drugs must be corrected. Gram negative bacteria are generally resistant to vancomycin Glycopeptide antibiotics including vancomycin, teicoplanin, vancomycin. These drugs are macromolecular structures that are not absorbed orally and require intravenous administration. Vancomycin is a classic example of this type of drug and a first-line drug against drug-resistant bacteria. Vancomycin has antibacterial activity against almost all gram positive bacteria, including coagulase positive or negative staphylococci, various streptococci, enterococci, Corynebacterium, anaerobic cocci, and monocytic Lester bacteria. Gram negative bacteria are generally resistant to vancomycin. So far, only a few resistant strains have been found in gram positive bacteria isolated from clinical isolates in china. The nationwide bacterial resistance surveillance network of Ministry of health showed that the resistance rate of enterococci was below 3%, and the resistant strains were not found in staphylococci and streptococci. The clinical efficacy of vancomycin is related to the dosage, and the daily dosage can be 2~3 times. As a kind of glycopeptide antibacterial agent developed in China, the antibacterial activity of vancomycin is similar to that of vancomycin. Teicoplanin large molecular weight and serum protein bind