脑缺血再灌注的利与弊（Advantages and disadvantages of cerebral ischemia and reperfusion）.docVIP

脑缺血再灌注的利与弊（Advantages and disadvantages of cerebral ischemia and reperfusion） Advantages and disadvantages of cerebral ischemia and reperfusion Based on the study of ischemic cerebrovascular disease, most of the research is ischemia reperfusion injury and talking to people, especially in animal experiments, researchers reported the most basic research papers are certainly ischemia-reperfusion damage to brain tissue, which makes people feel terrible of cerebral ischemia reperfusion. However, in clinical practice, clinicians try to improve the blood circulation of ischemic brain tissue, i.e., reperfusion, in order to save and protect the nerve cells. Therefore, cerebral ischemia and reperfusion in the end outweigh the disadvantages, or more harm than good, which deserves our deep thought. 1. the essence of ischemic cerebrovascular disease: ischemia refers to the obstruction of blood vessels and the reduction or suspension of local blood flow, leading to the dysfunction or (or) destruction of cellular function. Reperfusion refers to the recanalization of the blocked vessels or the opening of the surrounding collateral so that the ischemic tissue is partially or completely restored to the blood supply. Reperfusion injury is the increase of blood supply after ischemic tissue, but it causes the deterioration of the original lesion. Whatever the causes of ischemic cerebrovascular disease, its essence is because of reduced or suspended artery caused by focal cerebral ischemia or infarction, leading to nerve cell degeneration, necrosis, clinical manifestations of various symptoms and signs. Although many studies have shown that many factors can activate the ischemia induced brain ischemia cascade falls like lesions or a series of processes, but the most basic is the cause of ischemia, if not to solve this key problem, blocking any pathological chain reaction also has no obvious effect, can save the nerve cells degeneration and necrosis. Therefore, in terms of ischemic cerebr