乳糖在干粉吸入剂中的应用.PDFVIP

·综 述· 乳糖在干粉吸入剂中的应用 1 1,2* 2 曹伟 ，陈彦 ，张振海 (1.江苏大学药学院，江苏 镇江 212013 ；2. 国家中医药管理局中药释药系统重点研究室，江苏省中医药研究院 中药新型给药系统重点实验室，南京 210028) 摘要：目的 综述了乳糖在干粉吸入剂(dry powder inhalers ，DPI) 中的应用，为DPI 的研究和开发提供思路。方法 查阅 国内外相关文献，综述了载体乳糖(coarse carrier)的不同性质及加入微粉化乳糖(fine particles)对DPI 肺部沉积的影响。结 果 DPI 中的药物经微粉化后，其雾化性能下降。乳糖应用于DPI 中的研究分析表明，乳糖可以有效改善DPI 中药物的 雾化性能，从而提高药物在肺部的沉积效率，发挥最佳药效。结论 加入不同性质的载体乳糖和微粉化乳糖可以有效改 善药物在肺部的沉积效率。 关键词：乳糖；载体；微粉化乳糖；干粉吸入剂 中图分类号：R943.4 文献标志码：A 文章编号：1007-7693(2012)07-0591-06 Application of Lactose in Dry Powder Inhaler CAO Wei1 1,2* 2 , CHEN Yan , ZHANG Zhenhai (1.Department of Pharmaceutics, Jiangsu University, Zhenjiang 212013, China; 2.Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China) ABSTRACT: OBJECTIVE The application of lactose in dry powder inhalers (DPI) was reviewed and the ideas for research and development of DPI were provided. METHODS After looking up the related references published recently, home and abroad, the influenced of coarse carrier properties and added fine particles on pulmonary deposition of DPI were mainly summarized. RESULTS Aerosol performance of drugs in DPI is decreased after micronization. Research shows that the aerosol performance of drugs could be effectively improved by adding lactose, thereby the efficiency of drugs deposition in the lung is enhanced and the best potency is achieved. CONCLUSION The deposition of drugs in the lung could be effectively improved by adding coarse carrier with different properties and fine particles. KEY WORDS: lactose; coarse carrier; fine particles; dry powder inhaler 肺部药物传递系统(pulmonary drug delivery 乙醇等溶剂，对病变黏膜无刺激性；⑤药物呈干粉 system，PDDS)是一种输送药物到呼吸道和肺部， 状，稳定性好，干扰因素少，尤其适用