单光子发射型计算对宫颈癌化疗肾动态显像观察.docVIP

单光子发射型计算对宫颈癌化疗肾动态显像观察[摘要] 目的 探讨单光子发射型计算（SPECT）肾动态显像对宫颈癌患者化疗肾功能监测的临床意义。 方法 用SPECT及示踪剂99TcmDTPA对30例对照组及158例宫颈癌化疗患者进行肾动态显像，以了解患者肾功能情况。 结果 158例宫颈癌患者肾小球滤过率（GFR）降低。宫颈癌Ⅱ、Ⅲ期（化疗时间较长的）患者GFR均明显低于对照组，差异有显著性。部分患者（47.8%）尿素氮（BUN）及血肌酐（Scr）异常。 结论 宫颈癌患者化疗对肾功能均有不同程度的损害，且与化疗时间相关，SPECT肾动态显像可早期了解宫颈癌患者肾功能情况，以利于临床医生对患者情况了解及治疗。 [关键词] 宫颈癌；肾功能；肾动态显像；单光子发射型计算 [中图分类号] R737.33 [文献标识码] A [文章编号] 1673-7210（2012）07（b）-0028-02 Clinical observation of nephro-dynamic imaging for cervical carcinoma by SPECT HUANG Qingxia LI Xue WANG Yansheng WANG Jianchun ZHOU Jinhai ZHANG Qingfeng Department of Nuclear Medicine, the Central Hospital of Cangzhou City, Hebei Province , Cangzhou 061001, China [Abstract] Objective To explore the clinical value of single photon emission computed tomography of nephro-dynamic imaging for cervical carcinoma. Methods The nephro-dynamic imaging of control group (30 cases) and cervical carcinoma (158 cases) were observed by SPECT and 99Tcm DTPA. The renal function was evaluated. Results The glomerular filtration rate of cervical carcinoma was decreased. The GFR level of stage Ⅱand Ⅲ cervical carcinoma was lower than that of control group, with statistical significance. There were various abnormity of BUN and Scr in some people (47.8%). Conclusion There are various injury of renal function for cervical carcinoma, it is closely related to the duration of chemotherapy. The nephro-dynamic imaging of SPECT can early to understand the renal function of cervical carcinoma, and it is good for treatment. [Key words] Cervical carcinoma; Renal function; Nephro-dynamic imagine; SPECT 宫颈癌是女性最常见的恶性肿瘤之一，早期无任何症状，常在肿瘤发展到中晚期时以阴道不规则流血而就诊，严重威胁女性的健康和生命。仅2008年全球宫颈癌新发病例约53万，其中85%以上发生在发展中国家，因此已引起临床医生的高度重视[1]。由于宫颈癌对目前化疗药物不敏感，多采用其辅助治疗，但可引起肾功能损害。笔者采用单光子发射型计算（SPECT）肾动态显像，对宫颈癌患者的肾功能进行检测，现报道如下： 1 资料与方法 1.1 一般资料 选取2008～2011年我院门诊和住院治疗且化疗前肾动态检查正常或基本正常的宫颈癌患者158例，其中，宫颈癌Ⅱ期87例，年龄20～68岁，平均（37.65±9.85）岁；Ⅲ期71例，年龄22～72岁，平均（39.87±10.35）岁。所有患者均经病理证实为宫颈癌[2]，临床分期参照国际妇女产科协会（FIGO）、国际抗癌联盟（UICC）、美国癌症联合会（AJ