245例宫腔内人工授精夫妇染色体核型研究.doc

245例宫腔内人工授精夫妇染色体核型研究[摘要] 目的 探讨染色体核型多态性对夫精人工授精（AIH）妊娠结局的影响。 方法 对245对接受夫精人工授精（AIH）治疗的夫妇行外周血染色体核型分析，分析核型多态性与夫精人工授精治疗结局的关系。 结果 检出染色体异常核型和染色体多态性49例（发生率为10.0%），包括平衡易位2例（0.41%），4号、9号染色体臂间倒位15例（3.06%），Y染色体多态性2例（0.41%），其他染色体多态性30例（6.12%）。染色体核型正常组与染色体臂间倒位组比较，AIH周期临床妊娠率无差异（P ＞ 0.05），染色体核型正常组与常染色体多态性组比较，周期临床妊娠率有差异（P ＜ 0.05）。 结论 染色体臂间倒位对人工授精临床妊娠率无明显影响，常染色体多态性对AIH妊娠率并无负面影响。 [关键词] 染色体；染色体多态性;人工授精 [中图分类号] R715.2 [文献标识码] A [文章编号] 1673-7210（2012）08（b）-0040-03 Chromosome karyotype analysis among 245 couples with artificial insemination in uterine cavity CHEN Zhiheng SUN Ling QUAN Wumin Reproductive Medical Center, Guangzhou Women and Children Medical Center, Guangdong Province, Guangzhou 510623, China [Abstract] Objective To explore influence of karyotype polymorphism on pregnant outcome of artificial insemination to husband (AIH). Methods Chromosome karyotypes from peripheral blood of 245 couples accepting AIH were analyzed in order to find the relationship between karyotype polymorphism and pregnant outcome of AIH. Results The number of abnormal chromosome karyotype and karyotype polymorphism cases was 49, accounted for 10%. It contains four aspects: balanced translocation (2 cases), pericentric inversion of chromosome 4 and 9 (15 cases), Y chromosome polymorphism (2 cases), and other chromosome polymorphism (30 cases), at the percentages of 0.41%, 3.06%, 0.41%, and 6.12% respectively. There was no significant difference in clinical pregnancy rate of AIH cycle between normal chromosome karyotype and pericentric inversion group (P 0.05). However, the clinical pregnancy rate of AIH cycle showed a statistical difference between normal chromosome karyotype and autosomal polymorphism group (P 0.05). Conclusion The impact from pericentric inversion on AIH′s clinical pregnancy rate is very subtle, and there is no negative effect on AIH′s clinical pregnancy rate by autosomal polymorphism. [Key words] Chromosome; Chromosome polymorphism; Artificial insemination 不孕不育是妇科常见病，可