456例住院精神分裂症患者代谢综合征调查.doc

456例住院精神分裂症患者代谢综合征调查[摘要] 目的 调查住院精神分裂症患者代谢综合征（metabolic syndrome，MS）的患病率并分析其相关影响因素，为临床提供参考依据。 方法 对北京民康医院所有住院的精神分裂症患者进行调查，调查性别、年龄等人文情况，并测定其代谢指标，采用2004年中华医学会糖尿病分会代谢综合征诊断标准。 结果 共调查精神分裂症患者456人，严格依从诊断标准，结果精神分裂症代谢综合征的检出率为36.84%（168/456），其中男性MS检出率为31.25%，女性MS检出率为44.00%，男女性之间有显著差异。经Logistic回归分析显示，性别、年龄、体重指数（body mass index，BMI）对精神分裂症是否合并代谢综合征有显著性影响。 结论 女性精神分裂症患者代谢综合征患病率较男性高，尤其肥胖女性患者代谢综合征的患病率更高。 [关键词] 精神分裂症；住院患者；代谢综合征 [中图分类号] R749.3 [文献标识码] C [文章编号] 1673-7210（2012）08（a）-0124-03 Investigation of 456 hospitalized patients of schizophrenia with metabolic syndrome HUANG Wenping ZHAO Zu’an BAI Yuhong JIA Haitao DENG Shuo DING Lin Beijing Minkang Hospital, Beijing 102206, China [Abstract] Objective To investigate the prevalence of schizophrenia patients with metabolic syndrome (MS) and to analyze the related factors in order to provide a reference for clinical. Methods The hospitalized patients of schizophrenia with MS in Beijing Minkang hospital were all accepted the investigation and measurement of metabolic indicators. The investigation included gender, age and other humanities. The diagnostic criterion of 2004 Chinese medical sssociation diabetes branch of the metabolic syndrome was utilized. Results Strictly complied with the diagnostic criteria, the detection rate of schizophrenia MS was 36.84% (168/456), among it, the detection rate of male MS was 31.25% and female MS was 44.00%, there was significant differences between male and female. Logistic regression analysis: gender, age, BMI significantly affects schizophrenia with metabolic syndrome. Conclusion The prevalence of female schizophrenia with MS is higher than that of male, in particularly, the prevalence of obese female patients is much higher. [Key words] Schizophrenia; Hospitalized patients; Metabolic syndrome 近10年来随着第二代抗精神病药广泛应用于临床，其对血糖、血脂及体重等的影响，越来越显现出来，严重影响了精神分裂症患者的治疗依从性和治疗结局，而肥胖、血脂代谢异常、胰岛素抵抗和高血压等是代谢综合征（MS）的核心组成部分。代谢综合征在精神分裂症患者中具有更高的发病率，这可能与抗精神病药物不良反应及疾病本身等多种因素有关。本文旨在对我院住院精神分裂症患者代谢综合征的发病率及相关因素进行分析。