普彼特在应性皮炎中的应用.pptx

Calming the atopic dermatitis flare cycle with Protopic® VO: Atopic dermatitis is a disease of both skin barrier dysfunction and immune system hyperactivity.1,2 Super: Danby and Cork, Journal of Clinical Dermatology. 2010, 1(2):33-46 Cork et al., Journal of Allergy and Clinical Immunology. 2006, 118:3-21 VO: The stratum corneum can be thought of as a ‘brick wall’. Corneocytes are the bricks. Intercellular lipids acts as cement, while corneodesmosomes serve as iron rods embedded within the cement to stabilise the structure. 翻译： 翻译： 翻译： VO: In normal skin, the stratum corneum serves as a protection from irritants and allergens in the environment. VO: …allowing irritants and allergens from the environment… VO: In patients with atopic dermatitis, the stratum corneum is disrupted,2... Super: Cork et al., Journal of Allergy and Clinical Immunology. 2006, 118:3-21 翻译： 翻译： 翻译： VO: …to easily penetrate.2 Super: Cork et al., Journal of Allergy and Clinical Immunology. 2006, 118:3-21 VO: Allergen penetration in turn… Super: VO: …leads to the development of an allergic response and inflammation.3 Super: Cork M et al., Journal of Investigative Dermatology (2009) 129, 1892–1908 翻译： 翻译： 翻译： VO: In a recent study of quiescent AD patients, Protopic® has been shown to decrease trans-epidermal water loss significantly. Following treatment with Protopic®, trans-epidermal water loss improved significantly from baseline, whereas trans-epidermal water loss increased following betamethasone valerate cream treatment.6 Super: Danby et al., British Journal of Dermatology. 2014, 170:914-921 VO: As well as having an increased susceptibility to allergen penetration, a defective skin barrier is also responsible for increased trans-epidermal water loss, leading to dry skin.5 Super: Dähnhardt-Pfeiffer et al., JDDG. 2013, 11(5):437-443. VO: This is what AD skin looks like… Super: Dähnhardt-Pfeiffer et al., JDDG. 2013, 11(5):437-443. AD Skin 翻译： 翻译： 翻译： VO: A multifactorial disease requires a mult