复方降纤汤治疗慢性肝病病理细胞学探究.docVIP

复方降纤汤治疗慢性肝病病理细胞学探究[摘要] 目的：从病理细胞学的角度探讨中药联合抗病毒药物对慢性乙肝肝纤维化的治疗效果。方法：将50例慢性乙型病毒性肝炎肝纤维化（S3）患者随机分为治疗组和对照组，两组各25例。治疗组口服复方降纤汤联合阿德福韦酯6个月，对照组单用阿德福韦酯治疗6个月，治疗前后观察生化指标及肝组织切片的差异。结果：治疗组肝纤维化逆转率达88%，明显优于对照组（64%）。结论：复方降纤汤联合抗病毒药物治疗肝炎肝纤维化疗效满意，值得推广应用。 [关键词] 复方绛纤汤；慢性肝病；细胞学 [中图分类号] R575.2 [文献标识码] A [文章编号] 1673-7210（2011）12（b）-088-02 The study of pathological cytology on Compound Jiangxian Decoction in the treatment of chronic liver disease WU Jingxue1, WANG Huili1, GUO Junxia1, ZHANG Hongxia1, GUO Shuling1, SUN Yingjiang1, ZHANG Taoli2 1.Department of Internal Medicine, Guantao County People’s Hospital, Hebei Province, Guantao 057750, China; 2.Department of Internal Medicine, Beijing Geriatric Hospital, Beijing 100029, China [Abstract] Objective: To study the effects of Compound Jiangxian Decoction on chronic hepatitis B liver fibrosis in pathology cytology. Methods: 50 patients with chronic hepatitis B liver fibrosis were randomly divided into treatment group and control group. The treatment group was given Compound Jiangxian Decoction combined with Adefovir for 6 months, control group was only given Adefovir for 6 months. Biochemical indicators and liver biopsy were observed before and after treatment. Results: The efficiency in treatment group was 88%, significantly better than that in control group (64%). Conclusion: Compound Jiangxian Decoction combined with Adefovir is better than the use of Adefovir alone in the treatment of chronic hepatitis B liver fibrosis. [Key words] Compound Jiangxian Decoction; Chronic liver disease; Cytology 近几年来，我国慢性肝病有逐渐增多趋势，其病因多种多样，如乙肝、酒精、药物等。慢性肝病的病程和机制包括炎性反应、免疫反应、纤维化、肝硬化、肝癌等过程，其中肝纤维化是慢性肝病进展的必经阶段。一般来说，无论何种因素导致肝炎的发病都是从开始有炎症病变起即伴有肝纤维化，要想防治晚期肝病（肝硬化、肝癌）的发生，就必须阻断肝纤维化的进展。 清代名医王泰林在治肝十三法中提出散肝之法，药用逍遥散。《内经》有“木郁达之”，“肝欲散，急食辛以散之”之论，笔者现理解其散肝为上疏下通，肝气疏散，肝木舒通，以三焦通道为行径调理全身，五脏俱安。河南中医学院赵文霞教授在治疗慢性重型肝炎时注重祛湿邪详辨三焦，根据三焦辨证施药[1]。受前辈启发，从三焦论治慢性肝病，提出“舒通三焦，三焦通则肝自通”，并以此为理论指导自拟药方复方降纤汤治疗慢性肝炎取得较好疗效[2]。为进一步从细胞学角度证实复方降纤汤治疗慢性肝病的效果，笔者利用复方降纤汤联合阿德福韦酯治疗慢性乙型病毒性肝炎肝纤维化（S3）