厄贝沙坦氢氯噻嗪片治疗高血压疗效评价.docVIP

厄贝沙坦氢氯噻嗪片治疗高血压疗效评价[摘要] 目的 评价厄贝沙坦氢氯噻嗪片治疗高血压疗效。方法 患者随机分为两组：治疗组口服厄贝沙坦氢氯噻嗪片，对照组口服厄贝沙坦。两组患者用药均为1片/（次d），连续观察8周。对血压控制不佳者，剂量为2片/（次d）。结果 治疗组有效率为93.75%，对照组有效率为65.62%，两组比较差异有统计学意义（χ2=7.819，P=0.005）。结论 厄贝沙坦氢氯噻嗪片降压效果好，安全可靠，依从性好，值得临床借鉴使用。 [关键词] 复方制剂；厄贝沙坦氢氯噻嗪片；原发性高血压 [中图分类号] R544.1 [文献标识码] B [文章编号] 1673-9701（2011）31-138-01 Evaluation on Curative Effect of Iirbesartan and Hydrochlorothiazide Tablets in Treatment of Essential Hypertension FU Huaiwu Guanyun People’s Hospital in Jiangsu Province, Guanyun 222200, China [Abstract] Objective To evaluate curative effect of Iirbesartan and Hydrochlorothiazide Tablets in treatment of essential hypertension. Methods The patients were randomly divided into two groups. The treatment group was treated with Irbesartan and Hydrochlorothiazide Tablets, and the control group was treated with Irbesartan Tablets. Two groups of patients were medicated 1 tablet per time per day, but the patients with poorly controlled blood pressure were medicated 2 tablets per time per day. All patients were observed continuously for 8 weeks. Results The effective rate of treatment group was 93.75%, and that of the control group was 65.62%. Difference of efficiency between the two groups was statistically significant (χ2=7.819，P=0.005). Conclusion Irbesartan and Hydrochlorothiazide Tablets in antihypertensive effect is good, safe, reliable, compliant and worthy of clinical use. [Key words] Compound preparation; Irbesartan and hydrochlorothiazide tablets; Essential hypertension 近年来，随着社会变革和人们生活方式的变化，我国的心血管病发病率均有增长的趋势。据2002年全国居民营养与健康状况调查资料显示，我国18岁及以上居民高血压患病率为18.8%，估计全国患病人数1.6亿多。心脑血管病成为中国人首位死因，高血压是第一危险因素。有效治疗控制高血压能最大限度地降低心血管发病和死亡的总危险，提高患者生活质量[1]。2009年10月～2010年4月笔者对我院内科收治的高血压患者服用厄贝沙坦氢氯噻嗪片，取得了良好的疗效，现报道如下。 1 资料与方法 1.1 一般资料 1.1.1 诊断标准 所有患者按《中国高血压防治指南》（2005年修订版）[1]中“高血压的定义”诊断为高血压。 1.1.2 排除标准 继发性高血压者；心、脑、肾等重要器官有严重疾病者；妊娠及哺乳期女性；高钾血症者。 1.1.3 病例资料 入选的64例原发性高血压患者随机分为两组，各32例。治疗组男20例，女12例；年龄（60.09±11.18）岁；1级9例、2级15例、3级8例。对照组男18例，女14例；年龄（59.34±