脑结构定量分析22.pdfVIP

脑结构及功能定量研究 厦门大学附属中山医院磁共振科：林建忠 MRI Block Face Nissl Stain 脑结构研究内容  皮质（厚度，密度，脑沟折曲度（皮质折叠LGI），表面 积，体积）  白质（体积，V1 - 1st eigenvector V2 - 2nd eigenvector _V3 - 3rd eigenvector L1 - 1st eigenvalue L2 - 2nd eigenvalue L3 - 3rd eigenvalue MD - mean diffusivity FA - fractional anisotropy MO - mode of the anisotropy (oblate ~ -1; isotropic ~ 0; prolate ~ 1) S0 - raw T2 signal with no diffusion weighting)体素内交叉纤维，双侧白质（ 各个参数）不对称性及扩散峰度（DKI)。  深部灰质核团体积及向量改变  海马分区  胼胝体分区（六分法）  结构连通性（脑网络） 可定量灰质体积改变，像数改变， 可计算给个ROI各个数值及显著差异区域各种值 可计算每个差异区体素，体积及显著差异体素占脑区百分比 计算各个皮层厚度或统计后显著差异的不规则区脑区厚度，曲度，面积等 1300数据： 白质可的体积及密度 灰质，SurfArea GrayVol ThickAvg MeanCurv GausCurv FoldInd CurvInd Cortical Thickness Cortical Thickness  Distance between pial surface  Distance between white and pial surfaces white and pial surfaces  One value per vertex  One value per vertex  Surface-based more  Surface-based more accurate than volume- accurate than volume- based based white/gray surface lh.thickness, rh.thickness Curvature (Radial) Curvature (Radial)  Circle tangent to  Circle tangent to surface at each vertex surface at each vertex  Curvature measure is  Curvature measure is 1/radius of circle 1/radius of circle  One value per vertex  One value per vertex  Signed (sulcus/gyrus)