间隙连接蛋白43 渊Cx43冤在皮肤伤口愈合中的作用.PDF

246 生 命 科 学 研 究 圆园15 年 窑综 述窑 间隙连接蛋白43 渊Cx43 冤在皮肤伤口愈合中的作用 a, b a, b a, b a, b* 张才臻 , 母晓凤 , 贾东方 , 刁 勇 （华侨大学 a. 分子药 研究院; b. 生 医学学院，中国福建 泉州 362021) 摘 要 间隙连接渊gap junction, GJ冤是细胞膜上的通道结构袁其介导的细胞间间隙连接通讯渊gap junction inter鄄 cellular communication, GJIC 冤对内环境的稳定尧细胞生长调控及新陈代谢等起到重要的作用遥 间隙连接蛋白43 渊connexin43, Cx43 冤是哺乳动物细胞中分布最为广泛的间隙连接蛋白袁越来越多的研究发现皮肤创伤后Cx43 的表达会随着伤口愈合的过程发生动态变化袁并影响伤口愈合的速率和质量袁人为调控Cx43 的表达水平会改 善伤口愈合的速率和质量遥 主要就Cx43 结构与功能尧Cx43 的水平对伤口愈合各阶段的影响及Cx43 与慢性伤 口的关系进行总结袁以期为探索皮肤创伤袁尤其是慢性伤口治疗新途径提供参考价值遥 关键词 间隙连接蛋白43 渊Cx43 冤曰间隙连接曰伤口愈合曰慢性伤口 中图分类号 Q71 文献标识码 A 文章编号 1007-7847(2015)03-0246-06 The Effect of Connexin 43 (Cx43) on Cutaneous Wound Healing ZHANG Cai-zhena, b, MU Xiao-fenga, b, JIA Dong-fanga, b, DIAO Yonga, b* （a. School of Biomedical Sc ience ；b. Institute of Molecular Medicine, H uaqiao Unive rs ity Quanz hou 362021, Fuj ian, China ） Abstract: Gap junction is one of the most interesting and unique structures found between adjoining cells. Communication mediated by gap junction has important roles in internal environment homeostasis, cell pro liferation, differentiation, metabolism, and so on. Connexin 43 (Cx43) is the most widely distributed connexin in mammals. A growing number of researches have found that the expression of Cx43 is dynamically changed with the progress of cutaneous wound healing. The structure and functions of Cx43 ，relationship of Cx43 with stages of cutaneous wound healing are summarized, in order to provide reference value to find new therapies for cutaneous wound, especially for chronic wound. Key words: Connexin 43 (Cx43) ；gap junction ；wound healing ；chroni