激素-内毒素-Weight bearing does not contribute to the development of osteonecrosis of the femoral head.pdfVIP

Int. J. Exp. Path. (2012), 93, 458–462 O R I G I N A L A R T I C L E Weight bearing does not contribute to the development of osteonecrosis of the femoral head ,† †,‡ † † Shunichiro Okazaki* , Satoshi Nagoya*, Kenji Tateda , Ryuichi Katada , Keisuke Mizuo , Satoshi Watanabe†, Toshihiko Yamashita‡ and Hiroshi Matsumoto† *Departments of Musculoskeletal Biomechanics and Surgical Development, †Legal Medicine and Molecular Alcohology, and ‡Orthopedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan INTERNATIONAL SUMMARY JOURNAL OF The hip joint is one of the major structures in the human body and the resultant EXPERIMENTAL force acting through the hip joint is 300% of body weight. Therefore, weight bear- PATHOLOGY ing, as a cause of ischaemia, may contribute to the development of non-traumatic osteonecrosis of the femoral head (ONFH). However, it remains unclear whether weight bearing is related to the development of non-traumatic ONFH. Therefore the doi: 10.1111/j.1365-2613.2012.00836.x aim of this study was to clarify the role of weight bearing in the development of non-traumatic ONFH. Non-weight-bearing (NWB) rats were tail suspended to pre- vent any weight coming to bear on the hindlimbs from day 1 to the time of sacrifice. Received for publication: 31 March 2012 The weight-bearing (WB) group rats were also housed individually, although