单纯激素-Pravastatin reduces steroid-induced osteonecrosis of the femoral head in SHRSP rats.pdfVIP

Acta Orthopaedica 2012; 83 (1): 87–92 87 Pravastatin reduces steroid-induced osteonecrosis of the femoral head in SHRSP rats 1 1 1 2 Yoshihiro Nozaki , Kenji Kumagai , Noriaki Miyata , and Masami Niwa 1Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences; 2Department of Pharmacology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan Correspondence: kenjikum-ngs@umin.ac.jp Submitted 10-10-29. Accepted 11-09-26 Background and purpose Although the definite cause of steroid- bance, and disturbances of the coagulation-fibrinolysis system induced osteonecrosis of the femoral head (ONFH) is unknown, due to steroid hormones (Fisher 1978, Cheras 1997, Ichiseki peripheral circulatory failure, lipid metabolism disturbance, and et al. 2004, 2006). Statins are lipid-lowering, 3-hydroxy-3- increased oxidative stress are considered to be possible causes. We methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors investigated whether pravastatin as a statin treatment reduces (Endo 1992). Some statins have been reported to enhance the (1) the incidence of ONFH, (2) the adipocyte area, and (3) bone antioxidant activity and local lipid kinetics by directly acting marrow changes in the femoral head. on adipocytes and blood vessels, thus reducing the severity Methods We divided up 81 thirteen-week-old spontaneously and frequency of ONFH (Cui et al. 1997, Pritchett 2001, Ich- hypertensive stroke-prone (SHRSP)/Izm male rats into 4 groups: iseki et al. 2004, 2006, Nishida et al. 2008, Yagi et al. 2008