呼吸兴奋剂（Respiratory stimulant）.docVIP

呼吸兴奋剂（Respiratory stimulant） Respiratory stimulant Respiratory stimulant belongs to stimulants, mainly through respiratory excitement, but also by chemical stimulation of the carotid and aortic bodies feel excited for respiratory reflex, the dyspnea, increasing the ventilation volume, improve blood oxygen pressure, reduce blood pressure of carbon dioxide. Increase the sensitivity of the respiratory center to carbon dioxide, and when the respiratory center is in a state of inhibition, the excitatory effect is particularly obvious. Basic concept Physiological reaction analysis Generally speaking, the decrease of PaO2 and the increase of PaCO2 have a strong stimulating effect on the respiratory center. Compared with hypoxia and CO2, the latter is usually the main factor of respiratory center excitability. But in severe respiratory failure, reduce the sensitivity of respiratory center of CO2, CO2 increased stimulation no longer are the main factors causing respiratory excitement, now mainly rely on hypoxia to stimulate the chemoreceptor reflex excited breathing center, in order to maintain its excitability. Such as giving oxygen, exciting role of hypoxia on respiratory center is eliminated, the respiratory center but was inhibited, and re distribution of pulmonary blood flow, invalid cavity ventilation increase and other factors, making PaCO2 more increased. In addition, if the respiratory stimulant is applied, the respiratory depression caused by oxygen therapy can be avoided, and the goal of correcting hypoxia and CO2 retention can be achieved in time. Therefore, the use of respiratory stimulants to reduce PaCO2 and increase oxygenation is still of therapeutic value. Indications for use 1. use principle Mainly applicable to central inhibition, hypoventilation caused by respiratory failure, to cause pneumonia, pulmonary edema, diffuse pulmonary fibrosis with pulmonary ventilation dysfunction caused by respiratory failure is the use of respiratory stimulants. The princi