胰岛素样生长因子1受体基因rs2229765多态性与绝经后妇女骨质疏松的相关性.doc.docVIP

胰岛素样生长因子1受体基因rs2229765多态性与绝经后妇女骨质疏松的相关性.doc.doc

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胰岛素样生长因子1受体基因rs2229765多态性与绝经后妇女骨质疏松的相关性.doc

胰岛素样生长因子1受体基因rs2229765多态性与绝经后 妇女骨质疏松的相关性 王 玉1,郭天康2,刘 静3,杨睿斐3,邵菲菲3,田利民3 (1甘肃中医药大学临床医学院,甘肃省兰州市 730000;甘肃省人民医院, 2普外科,3内分泌科,甘肃省兰州市 730000) 引用本文:王玉,郭天康,刘静,杨睿斐,邵菲菲,田利民. 胰岛素样生长因子1受体基因rs2229765多态性与绝经后妇女骨质疏松的相关性[J].中国组织工程研究,2017,21():1813-1818. DOI:10.3969/j.issn.2095-4344.2017.12.002 ORCID: 0000-0003-2938-4928(王玉) 文章快速阅读: 文题释义: 多态性:胰岛素样生长因子1:Association of insulin-like growth factor 1 receptor gene rs2229765 polymorphism with osteoporosis in postmenopausal women Wang Yu1, Guo Tian-kang2, Liu Jing3, Yang Rui-fei3, Shao Fei-fei3, Tian Li-min3 (1School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China; 2Department of General Surgery, 3Department of Endocrinology, Gansu Provincial People’s Hospital, Lanzhou 730000, Gansu Province, China) Abstract BACKGROUND: Insulin-like growth factor 1(IGF-1) plays an important role in regulating osteocyte function and bone metabolism. The association of insulin-like growth factor 1 receptor (IGF-1R) gene polymorphisms with osteoporosis in postmenopausal women has not yet been reported. OBJECTIVE: To investigate the correlation between IGF-1R gene rs2229765 single nucleotide polymorphism and osteoporosis in postmenopausal women. METHODS: IGF-1R gene rs2229765 SNPs were detected using PCR-RFLP in 218 patients with postmenopausal osteoporosis and 270 postmenopausal women with normal bone mineral density. The bone mineral density of the lumbar spine, femoral neck and forearm was determined by dual-energy X-ray absorptiometry. Serum IGF-1 level was investigated by ELISA. RESULTS AND CONCLUSION: The AA genotype (29% vs. 17%, P=0.001) and A allele (51% vs. 40%, P=0.000) distributions of the rs2229765 polymorphism in the osteoporosis group were significantly higher than those in the control group. Compared with GG genotype of rs2229765, AA genotype was significantly associated with an increased risk of osteoporosis (OR=2.12, 95%CI=1.27-3.54, P=0.004). The analysis of serum IGF

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