尘螨变应原皮肤点刺试验等级对特异性免疫治疗效果的影响.pdfVIP

CHIN ARCH OTOLARYNGOL HEAD NECK SURG / June 2016, Vol.23, No.6 345 DOI: 10.16066/j.1672-7002.2016.06.011 尘螨变应原皮肤点刺试验等级对特异性免疫治疗效果的影响 郭杰峰，伍慧卿，林丽莉，赵晓明，熊彬彬，刘钊 暨南大学医学院第三附属医院珠海市人民医院耳鼻咽喉科，广东　珠海　519000 [摘　要]　目的　观察粉尘螨、屋尘螨变应原皮肤点刺 [ABSTRACT]　OBJECTIVE　To observe the efficacy 试验（skin prick test ，SPT）等级不同的变应性鼻炎患儿应 of specific immunotherapy (SIT) with Alutard and NHD in 用安脱达和阿罗格标准化尘螨疫苗进行特异性免疫治疗 children with allergic rhinitis due to different level of skin （specific immunotherapy，SIT）的疗效。 　将确诊为 prick test (SPT) with dermatophagoides farinae (DF) and 方法 持续性变应性鼻炎的6 ～12岁患儿按SPT等级分3组，I组：粉 dermatophagoides pteronyssinus (DP). METHODS 尘螨皮肤指数（skin index ，SI ）大于屋尘螨组，II组：粉尘 A total of 178 children with persistent allergic rhinitis were 螨SI等于屋尘螨组，III组：粉尘螨SI小于屋尘螨组。再采用 included in this study. Their age ranged from 6 to 12 years. 随机分组方法将每组内患儿分为安脱达组和阿罗格组，并 They were divided into 3 groups according to level of SPT. 给予相应药物SIT 1年，观察记录并分析比较患者症状得分 Group 1: The level of skin index (SI) of DF is greater than 及药物评分。 　I、II组患者治疗3个月、6个月时症状得 that of DP, Group 2: The level of SI of DF is equal to that of 结果 分及药物评分改善情况阿罗格组优于安脱达组，2组间差 DP and Group 3: The level of SI of DF is less than that of 异有统计学意义（P ＜0.05 ）；III组患者治疗3个月、6个月时 DP. The children in each group were randomly divided into 症状得分及药物评分改善情况安脱达组优于阿罗格组，2组 2 subgroups: Alutard group and NHD group. The children 间差异有统计学意义（P ＜0.05）；I、II、III组患者治疗9个月、 were given SIT with Alutard or NHD for one year. Symptom 12个月时安脱达组和阿罗格组症状得分及药物评分改善情况 and medication scores were recorded and analyzed. 差异无统计学意义（P ＞0.05）。 　粉尘螨、屋尘螨SPT等 RESULTS 结论 　After receiving therapy for 3 months and 6 级不同的变应性鼻炎患儿应用安脱达和阿罗格标准化尘螨 months, symptom and medication scores of the Group 1 and 疫苗进行SIT 3个月、6个月时疗效不同，9个月、12个月时疗效 2 in the NH