hedgehog信号通路及其抑制物在抗肿瘤治疗中的研究进展 - tumor.pdf

178 肿瘤2011年2月第31卷第2期 Tumor Vol. 31, February, 2011 DOI:10.3781/j .issn.1000-7431.2011.02 .018 Review ·综述 Hedgehog信号通路及其抑制物在抗肿瘤治疗中的研究进展 王 娟，陈秀华 上海医药工业研究院药理室，上海 200437 [摘要]  目的：Hedgehog信号通路不仅与胚胎的发育、组织的形成、成人组织再生及修复相关，同时已被证实与 多种肿瘤细胞的形成、生长和转移具有相关性。当该信号通路异常激活时，会引起肿瘤的发生和发展。因此， 对多种肿瘤中Hedg ehog 信号通路的了解，将有助于针对其特异性治疗药物的研发和应用。目前，第一个针对 Hedgehog信号通路的小分子抑制剂GDC-0449 已进入临床试验阶段，并显示了良好的临床疗效。本文就此途径与 肿瘤的关系及在肿瘤治疗中的应用进行综述。 [关键词]  肿瘤；抗肿瘤药，植物；信号转导；Hedgehog信号通路 [中图分类号]  R730.5           [文献标志码]  A               [文章编号]  1000-743 1 （20 11）02-0 178-05 Progress in Hedgehog signaling pathway and its inhibitors for anti-tumor therapy WANG J uan, CHEN X iu-hua Department of Pharmacology , Shanghai Institute of Pharmaceutical Industry , Shanghai 200437, China [A BSTRACT] Hedgehog signaling pathway is not only related w ith the development of embryo, formation of organ, and the regeneration and repair of tissues in adults, but also plays an important role in the growth and metastasis of tumor cells. A berrant activation of this pathway has been found to be involved in the development of cancer. Understanding the mechanism of Hedgehog signaling pathway in various tumors is critical to the development and the use of specific agents targeting this pathway . GDC-0449 is the first small-molecule Smo-inhibitor entering clinical trials, and it shows clinical benefit. T his article summarizes the relationship between the Hedgehog signaling pathway and the progression of tumor, and addresses the practical application of this pathway in tumor therapy . [KEY WORDS]  Neoplasms; Antineoplastics agents, phytogenic; Signal transduction; Hedgehog signaling pathway [Tumor,2011,31(2):178-182] 近年来大量的研究表明，Hedgehog 信号通路不仅在 在 3 个 Hedgehog 的 同源 基 因sonic hedgehog （Shh ）、 胚胎