N-乙酰半胱氨酸治疗特发性肺纤维化的疗效观察.pdfVIP

· 18· 医药论坛杂志 2008年2月 第29卷 第4期 N一乙酰半胱氨酸治疗特发性 肺纤维化的疗效观察 杨志刚，马希涛，王思勤 河南省人民医院呼吸科 郑州市 450003 摘要 目的 了解N一乙酰半胱氨酸(NAC)对特发性肺纤维化(IPF)的治疗效果。方法 选择IPF患者 32例为研究对象，随机分为试验组和对照组。试验组予以N一乙酰半胱氨酸治疗，对照组用糖皮质激素治疗。 观察各组治疗前后症状及肺功能改善情况及不良反应。结果 ②试验组总有效率为82、35％，对照组为 80．00％，两组总有效率差异无统计学意义(P0．05)。② 两组治疗后，PaO2、PaCO2、FVC、FEVl／FVC、MVV、 DLco、DIx：o／VA等指标均较治疗前升高(P0．05)。治疗后各指标在两组间的差异无统计学意义(P0．05)， 表明对肺功能改善的疗效相当。③试验组患者未发现不良反应。结论 NAC能有效改善IPF的症状及肺功能。 关键词 N一乙酰半胱氨酸；特发性肺纤维化；治疗 中图分类号：R563．1 3 文献标志码：B 文章编号：1672-3422(2008)04-0019-03 Observation on Treating Effect of N——acetylcystein on Idiopathic Pulmonary Fibrosis YANG Zhigang，MA Xitao，WANG Siqin Department of Respiratory Medicine，Henan Provincial People’S Hospital，Zhengzhou 450003，China ABSTRACT Objective To know the effects of N—acetylcystein(NAC)on idiopathic pulmo- nary fibrosis(IPF)．Methods Total 32 patients who suffered from IPF were selected as the study ob- jects．All of them were randomly divided into 2 groups：observation group and control group．Observa- tion group were treated with NAC，while control group were treated with hormone．The clinical manifes- tation，pulmonary function testing，arterial blood gas analysis were observed before and after treatment， and the adverse reaction was observed after treatment．Results①The efficient rate of observation group was 82．35％ ，and that of control group was 80％．There was no statistical difference between the two fig- ures(P0．05)．②As far as PaO2、PaCO2、FVC、FEVl／FVC、MVV、DLco、DLco／VA were concerned， both group were better after treating．After treating，there was no statistical difference of that parameters between the two groups．⑧There was no drug adverse