分子医学概论（Introduction to molecular medicine）.docVIP

分子医学概论（Introduction to molecular medicine） 1 molecular medicine? The term molecular medicine was presented in the form of a headline in authoritative magazine and thematic academic conferences by prominent scientists in the field of biomedical frontiers in 1994. In February 1994, the United States national institutes of health (NIH) in the tumor research institute, general ((Karp) and broad ((Broder) in the journal cancer research, published an article called the new direction of molecular medicine lengthy commentary, introduces in detail the main progress of molecular medicine. In September 1994, held in San Francisco organized by the journal nature, molecular medicine seminar, the journal nature on the published essay, titled the challenge of molecular medicine is the influence of the development of medical molecular biology and the problems faced by comments. In 1995, from basic and clinical studies in the field of molecular medicine editorial published in the journal molecular medicine scientists has officially launched, it marks the modern biological medicine has entered the new stage of the molecular medicine. According to the definition of karp, the contents of molecular medicine include the discovery of basic molecules that control the behavior of normal cells; To understand the relationship between abnormal gene expression and gene interaction disorder and disease. These abnormal genes are examined and corrected for diagnosis, treatment and prevention. The main difference between molecular medicine and traditional medicine is that the former is both at the molecular and genetic level. 1.1 molecular mechanism of disease Rapid development of molecular biology and the medical wide first is in terms of basic research, find out some molecular systems that regulate cell behavior, such as cell signal transduction, the molecular basis of some important structure and function of the enzyme and biological molecules and their encoding genes, cancer protein, tumor-supp