一项基于体素的形态学测量.PDFVIP

·1180 · doi 10.3969/j.issn. 1673-4254.2015.08.19 J South Med Univ, 2015, 35(8): 1180-1183 临床研究 三三叉神经痛患叉神经痛患者脑灰质结构的变化者脑灰质结构的变化：：一项基于体素的形态学测一项基于体素的形态学测量量 颜剑豪，李 盟，汪天悦，詹文峰，江桂华 广东省第二人民医院影像科，广东 广州 510317 摘要：目的运用基于体素的形态学测量（VBM）方法分析三叉神经痛患者（TNP）和正常对照组间全脑灰质体积的差异。方法 采用PHILIPS 1.5T 磁共振扫描仪对28 例TNP 患者和28 例正常对照进行全脑高分辨结构像扫描。采用SPM8对采集的三维结 构像数据进行预处理，利用DARTEL 对全脑结构进行VBM 分析，并以双样本t 检验比较两组被试灰质体积的差异。结果 与正 常对照组相比，TNP 显示双侧大脑半球广泛脑区的灰质体积减少，这些减少的区域主要位于双侧颞中回，双侧额上回，额中回， 左侧中央前后回，右侧梭状回，前扣带回等区域。结论 VBM 揭示了TNP 存在广泛脑区灰质密度异常，这些脑区基本属于疼痛 的感知和处理区域。此外，这种脑结构改变有助于对TNP 神经机制的探讨。 关键词：三叉神经痛；灰质体积；VBM ；磁共振成像 Structural changes in the gray matter in patients with trigeminal neuralgia: a voxel-based morphometric study YAN Jianhao, LI Meng, WANG Tianyue, ZHAN Wenfeng, JIANG Guihua Department of Medical Imaging, Guangdong Second Provincial Peoples Hospital, Guangzhou 510317, China Abstract: Objective To investigate the changes in whole brain gray matter volume in patients with trigeminal neuralgia using voxel-based morphometry (VBM). Methods Twenty-eight patients with trigeminal neuralgia and 28 healthy controls underwent magnetic resonance imaging with a Philips 1.5T MRI scanner. VBM was used to compare the structural differences in the whole brain gray matter between the two groups based on the DARTEL after data preprocessing with SPM8 software package. Results Compared with the healthy controls, the patients with trigeminal neuralgia presented with decreased gray matter volume in several brain regions including the bilateral middle temporal gyrus, bilateral superior/middle frontal gyrus, left pre-/post-central gyrus, right fusiform and anterior cingulate gyrus. Conclusions Patients with trigeminal neuralgia had abnormal gray matter volume in some brain regions associated with perception and processing of pain sensation. These changes may provide clues for further exploration of the neuropatho