9例钙化上皮瘤临床特点及病理研究.doc

钙化上皮瘤临床特点及病理研究 9 例）钙化上皮瘤患者年龄小于29 岁，病变全部位于头颈部及上臂，77.78%（7/9例）的患者临床误诊为其他疾病，手术切除后均无复发，组织病理观察，其镜下表现为典型的嗜碱性细胞及影细胞排列为主。结论 钙化上皮瘤好发于青少年，其临床误诊率较高，手术彻底切除可预防复发，此病变具有多样化的临床表现，对颈部、上臂、头面部皮肤单个结节，应考虑钙化上皮瘤的可能 关键词： 钙化上皮瘤；组织学特征；病理 中图分类号： 文献标识码： 文章编号： Clinical and Pathological Features of Calcifying Epithelioma YIN Jian1, WANG Chang-song1, FAN Nai-jun2，MENG Niang-long1, YUAN Xun-tao1, QIAO Liang1 1Department of Pathology, 2Institute of Colorectal Surgery, 150th Central Hospital of PLA, LuoYang,471031 [Abstract Objective] Totudy the clinical and pathological features of calcifying epithelioma. Methods By a retrospective experimental design, the clinical and pathological features of 9 cases calcifying epithelioma, pathology diagnosed by the pathology department after surgical resection from January of 2005 to December of 2009, were reviewed by our group. Results The diseased region were upper arm, head and neck: 88.89% (8/9 cases) calcification of epithelial tumors were younger than 29 years , 77.78%（7/9 cases）were misdiagnosis as others diseases, and without recurrence after surgical resection. The basophilic and shadow cells were arranged mainly in tissue . Conclusion Calcifying epithelioma the characteristics of occuring mainly in upper arm, head and neck of young people, higher rate of clinical misdiagnosis, without recurrence after surgical resection, and a variety of clinical manifestations, which may contribute to its diagnosis. Key word： Calcifying Epithelioma;histological features; Pathology 钙化上皮瘤又称毛母质瘤，是一种良性肿瘤，来源于毛发母细胞皮肤真性肿瘤，局部有侵袭性，但是恶变十分罕见，肿瘤内容物多为钙化物，故称为钙化上皮瘤[l]。由于钙化上皮瘤发生率很低，临床报道较少，从而临床认识不足，常被误诊，延误治疗。为此我们收集了2005年1月至2009年12月在解放军第150中心医院就诊经术后病理诊断为钙化上皮瘤的患者9例进行回顾性分析。旨在探讨钙化上皮瘤的临床病理特点，进而提高诊断水平。 1 临床资料与方法 以2005年1月至2009年12月在解放军150医院的手术切除并经病理证实为钙化上皮瘤患者9例为研究对象，回顾性分析其临床表现、组织病理学特点及预后。 2 结果 2.1 患者一般资料 9例钙化上皮瘤患者中，男性患者6例，女性患者3例，男女比例2:1。年龄分布在2～43岁，平均年龄20.4岁，其中1～10岁患者3例，11～20岁患者1例，21-30岁患者4例，＞30岁患者1例。病程最短1个月，最长5年，发生部位：颈部4例，头部2例，上臂2例，颊部1例。 2.2 临床症状 9例钙化上皮瘤患者中均为单一性孤立皮下包块，大小0.5cm2.5cm。切面