日本筑波大学曾对122名原发肝细胞癌患者进行质子治疗.pptVIP

Pre-conceptual design of Energy Modulation Ion Therapy (EMIT) YK Heng Represents EMIT group Institute of High Energy Physics April 30, 2008 @ USTC, Hefei 主要人员 总体设计 韦杰/方守贤 快循环同步加速器物理设计 焦毅/王生 基于直线加速器的注入器 傅世年 回旋加速注入器 唐靖宇 环注入、引出、传输线及束流配送 唐靖宇 机械系统预制研究 屈化民 电气系统预研 张旌 旋转机架设计 屈化民/唐靖宇 治疗头设计 衡月昆/刘力 成像与定位系统 舒航 控制及安全联锁系统 上海光源 刘德康 Outline General introduction with proton/ion therapy Clinical Requirements and EMIT advantages Main pre-conceptual design: Accelerator (Injector, Synchrotron, Delivery ) Therapy (Gantry, Nozzle, positioning ) Control and software (TCS, TPS, dose verification ) Summary Part I General introduction with proton/ion therapy Comparison of irradiation therapy Dose and effects comparison Demands and status 20%人死于肿瘤，我国每年至少有240万发病的肿瘤病人，其中适应放疗的病人约为100万人 治疗费用：10~20万RMB 装置费用：3亿~10亿RMB 世界上,正式运行的约30台，正在建造中或计划建造的粒子治疗装置共有14台。 其中美国9台、日本8台、德国6台、法国4台、俄罗斯3台、意大利3台、瑞士3台、南非2台、英国1台、瑞典1台、加拿大1台、奥地利1台、韩国1台。 中国1~3台 Part II Clinical Requirements and EMIT advantages Clinical Requirements Range in patient：3.5～35g/cm^2 (beam 60~250MeV) Range Adjustment precision：0.1g/cm^2 @ 60MeV: 1Mev variation is relative to 1mm depth; @ 220MeV: 1Mev variation is relative to 2.5mm depth Average Dose rate：2Gy/min (Scattering) 20Gy/min (Scanning) Field size：20cmX20cm Dose uniformity：±4% Beam Positioning resolution at isocenter: ± 0.5mm EMIT main parameters Energy Modulation AC advantages AC can adjust precise energy: 1MeV, spread 0.2% Beam intensity modulation: factor of ~ 100 7 by chopping the beam to different length (50 - 350 ns). Another factor of 15 by source current adjustment collimation EMIT layout Part III Main pre-conceptual design: Accelerator (Injector, Synchrotron, Delivery ) Therapy (Gantry, Nozzle, positioning ) Control and software (TCS, TPS, dose verification ) EMIT-p injector: IS + RFQ + DTL EMIT-p rapid c