DNA编码分子库DNA-encoded drug libraries come of age.pdfVIP

N E W S Wellness ’omics in clinics DNA-encoded drug libraries come of age Providence Health Services has joined forces with the Institute of Systems Biology DiCE Molecules, a company with a new for an interaction between the target and small (ISB) to offer clinical care focused on approach to DNA-encoded chemical librar- molecules. keeping patients healthy, using analytics ies, signed a deal in March worth $2.3 billion The simple experimental setup of DNA- to predict, prevent, or detect the onset of disease before clinical symptoms develop. with French pharma Sanofi. The Paris-based encoded chemical screens also means that In March, Providence became affiliated with drugmaker will pay DiCE an initial $50 mil- they require very little target protein, whereas the not-for-profit ISB, located in Seattle and lion to access DiCE’s ‘directed-evolution’ tech- HTS requires enough founded by systems biologist Leroy Hood, nology and up to $184 million in milestones target to add to each immunologist Alan Aderem, and protein per target. In January, Sanofi also inked a drug well. An entire DNA- chemist Ruedi Aebersold. The partners aim to provide insights into wellness and disease discovery deal with X-Chem, a biotech with a encoded library can by generating dense, personalized clouds DNA-encoded drug discovery platform, based