抑郁症患者静息态功能磁共振成像和弥散张量成像 - 第三军医大学学报.DOCVIP

抑郁症患者局部脑功能静息态磁共振成像研究 王晓霞1，蒋成刚2，冯正直1（400038重庆，第三军医大学护理系心理教研室1；400042 重庆，第三军医大学大坪医野战外科研究所院神经内科2） [摘要] 目的 通过静息态功能磁共振成像技术和局部一致性（regional homogeneity, ReHo）分析方法，探讨抑郁症患者基础状态下自发神经活动特点及脑功能变化。方法 选取年龄、性别和文化程度匹配的10例抑郁症患者和13例正常对照组被试，采用DPARSF软件进行静息态功能数据的预处理，计算两组被试全脑的ReHo值采用SPM5软件对两组全脑ReHo值进行基于体素的组间比较，考察抑郁症患者和正常对照组静息状态脑功能差异。结果 与正常对照组相比，抑郁症患者存在涉及顶叶、颞叶和边缘叶等多个认知控制和情绪加工相关脑区的自发神经活动异常，其中右侧丘脑、左侧下顶叶、缘上回、右侧小脑、右侧顶内沟和右侧齿状回表现出功能一致性增强(P0.01)，中脑和右侧后扣带回功能一致性减弱(P0.01)。结论 抑郁症患者存在多个脑区的静息态功能一致性异常,这些区域多与认知控制和情绪加工有关。 [关键词] 局部一致性；静息态；抑郁症；功能磁共振成像 The regional brain functional connectivity of depression in resting state Wang Xiaoxia1, Jiang Chenggang2, Feng Zhengzhi1 (1Department of Psychology, School of Nursing, 2Department of Clinical Psychology, Daping Hospital, Third Military Medical University, Chongqing, 400038) [Abstract] Objective To examine spontaneous neural activity and resting state functional alteration in patients with major depression by resting state functional magnetic resonance imaging (rsfMRI) . Methods Ten participants diagnosed with major depression, and thirteen healthy controls matched with age, gender and education were recruited and scanned with resting state fMRI. An regional homogeneity (ReHo)approach was acquired for data processing. Resting sate imaging Data was preprocessed and calculated for whole brain ReHo by DPARSF software, and then raw data was entered into the SPM for two independent sample T test(p0.01, uncorrected) Results The ReHo maps were obtained. We found a diffuse ReHo increase in patient group, that was distributed over parietal lobes, temporal lobes and limbic lobes, including right Thalamus, left inferior parietal lobe, supramarginal gyrus, right cerebellum, right intraparietal sulcus and right fusiform gyrus. Intriguingly our findings also indicate the sign of decreased ReHo in depression in midbrain and right posterior cingulate gyrus, which differed from prior findings and remained to be elucidated in future. Conclusion Abnormali