TP方案及PF方案化疗治疗晚期食管癌近期疗效对比分析.docVIP

TP方案及PF方案化疗治疗晚期食管癌近期疗效对比分析 　　DOI：10.16662/j.cnki.1674-0742.2017.07.099 [摘要] 目的 探讨TP方案化疗与PF方案治疗晚期食管癌的近期疗效。方法 回顾性分析2013年4月―2016年3月该院收治的晚期食管癌患者60例，分为TP组（n=36；紫杉醇135 mg/m2 d1；顺铂20 mg/m2 d1-3）与PF方案组（n=24；5-氟尿嘧啶500 mg/m2泵持续推注 d1-5；顺铂 25 mg/m2 d1-3）；观察两组患者的近期疗效及毒性反应。结果 TP组近期有效率为69.44%，明显比PF组高（41.67%）（P0.05）。 结论 TP（紫杉醇联合顺铂）方案化疗能提高晚期食管癌患者的近期疗效，同时其毒副反应发生率并未增高，可认为安全有效 [关键词] TP方案；PF方案；晚期食管癌 [中图分类号] R4 [文献标识码] A [文章编号] 1674-0742（2017）03（a）-0099-03 Comparative Analysis of Long-term Curative Effect of TP Plan and PF Plan Chemotherapy in Treatment of Esophageal Cancer CHEN Qing， MA De Department of Oncology， Jingjiang Peoples Hospital， Jingjiang， Jiangsu Province， 214500 China [Abstract] Objective To observe and analyze the long-term curative effect of TP plan and PF plan chemotherapy in treatment of esophageal cancer. Methods 60 cases of patients with esophageal cancer admitted and treated in our hospital from April 2013 to March 2016 were retrospectively analyzed， and divided into the TP group and PF group， the TP group （n= 36） adopted the taxinol of 135 mg/m2 d1 and cis-platinum complexes of 20 mg/m2 d1-3， the PF group （n=24） adopted the 5-fluorouracil of 500 mg/m2 and cis-platinum complexes of 25 mg/m2 d1-3， and the long-term curative effect and toxic reaction of the two groups were observed. Results The long-term effective rate in the TP group was obviously higher than that in the control group， （69.44% vs 83.33%）（P0.05）. Conclusion The TP plan chemotherapy can improve the long-term curative effect of patients with esophageal cancer but it doesnt increase the incidence rate of toxic reactions， which can be regarded safe and effective. [Key words] TP plan； PF plan； Esophageal cancer 食管癌?儆谙?化道肿瘤疾病，我国食管癌发病率与病死率在恶性肿瘤中分别位居第五与第四，对患者生命安全造成极大的威胁[1-2]。患者发病初期无明显临床症状，就诊时多数已为局部晚期或已发生转移，错失最佳手术时机[3]，对于失去手术机会的晚期食管癌患者，姑息治疗联合化疗是主要治疗手段[4]。该院分别采用紫杉醇联合顺铂（DDP）和5-氟尿嘧啶（5-FU）联合顺铂化疗对2013年4月―2016年3月期间治疗收治的60例晚期食管癌患者进行治疗，比对了两组的疗效和不良反应，现报道如下 1 资料与方法 1.1 一般资料 方便选取该院诊治的60例