光照疗法对轮班睡眠时相障碍患者昼夜节律恢复作用疗效观.PDFVIP

中国临床神经科学20 13 年第2 1 卷第3 期 284 Chin J Clin Neurosci 2013,21 (3),284~288 论 著 光照疗法对轮班睡眠时相障碍患者昼夜节律恢复作用的 疗效观察 郎 莹，蒋晓江，马国重，李训军，钟代曲，刘雅贞 (第三军医大学大坪医院野战外科研究所神经三科400042) 关键词 光照疗法；体温节律；轮班睡眠时相障碍；昼夜节律 摘要 目的 探讨光照疗法对轮班睡眠时相障碍患者昼夜节律的恢复作用。方法 纳入30例因轮班导致睡眠时相障碍 的患者，入选后随机分入光照治疗组( 15 例) ，对照组( 15 例，戴眼罩屏蔽光线) 。两组均于相应体温节律最低点后10 min 开始予以光照治疗。总治疗时间为3 d ，每次治疗时间2 h ，共3 次治疗。于治疗前后采用阿森斯失眠量表分别评 估两组患者的疗效，并监测治疗前后的体温节律变化。结果 光照治疗后，治疗组阿森斯失眠量表分值较治疗前降 低(P0.05) ，体温节律曲线较治疗前呈前移趋势，与治疗前比较，差异有统计学意义(P0.05) 。对照组治疗后阿森斯失 眠量表分值较治疗前，差异无统计学意义(P0.05) ，体温节律曲线未见明显移位(P0.05) 。不良反应小。结论 光照疗 法可有效改善轮班睡眠时相障碍患者的睡眠质量，使患者昼夜时相的体温节律发生位移，纠正紊乱的昼夜节律使之逐 步恢复至正常状态，是治疗轮班睡眠时相障碍患者的有效手段。 Therapeutic Effect of Light Therapy on Circadian Rhythm for the Shift Work Disorder Patients LAN G Ying, JIAN G X iao-j iang, MA Guo-zhong, LI X un-j un, ZH ON G Dai-qu, LI U Ya-zhen Department of Neurology Disease, Institute of Surgery Research, Daping Hospital, the Third Military Medical University, Chongqing 400042, China KEY WORDS light therapy ; temperature rhythm; shift work disorder; circadian rhythm ABSTRACT Aim To explore the therapeutic effect of light therapy on circadian rhythm for the shift work disorder patients. Methods 30 workers with shift work disorder were studied. They were randomly divided into two groups. 15 patients in the treatment group were given light therapy after body temperature rhythm nadir 10 min later for 3 days, 2 hours each time, while 15 patients in the control group were given the same treatment, but they would wear eyepatch in order to shield light. Athens Insomnia Scale （AIS）and temperature rhythm curve were also detected and compared between the pre-treatment and post-treatment groups. Results The scores of AIS were lower than those before the treatment (P0.05) in the treatment group. The acrophase of tempera