计算机辅助诊断在肝脏灌注中的应用.pdfVIP

摘要 摘要 随着科技的进步，CT 灌注成像在疾病诊疗方面发挥着日趋重要的作用。CT 灌注成像是从组织细胞和微循环水平来评估组织的生理病理状态，是医学图像处 理领域的热点之一。近年来，CT 灌注成像在头部的应用日益成熟，但在肝脏中的 应用却发展缓慢。因为肝脏具有复杂的双重供血系统，与CT 头部灌注成像相比， CT 肝脏灌注成像更为困难。本文的目的是开发一套针对CT 肝脏灌注的CAD 软件， 该软件可计算各项肝脏灌注参数，并生成功能图像，从而提高医生对肝脏疾病的 诊断质量和诊断效率。 本文主要做了以下几方面工作：首先，介绍了灌注成像的基本原理，以及几 种灌注的数学模型和灌注成像的主要参数。其次，研究并实现三种计算肝脏灌注 参数的算法，并嵌入研发的CT 肝脏灌注CAD 软件中。此外，在常规的双输入模型 算法的基础上，提出了相应的改进方法，并与原双输入法和斜率法进行了比较。 结果表明，改进后的算法比原算法计算灌注参数更为精确，与较为稳定的斜率法 计算出的参数有很好的一致性。最后，使用一组真实的肝癌CT 数据和一组正常肝 脏CT 数据来对所研发的软件进行测试，结果表明，软件的所有算法均可使肝癌病 灶部分在功能图像上更为突出的显示出来，且操作方便，能够辅助医生对肝脏病 变进行检测。 关键词：灌注成像 计算机辅助诊断 肝脏 血流量 计算机断层扫描 Abstract Abstract With the development of science and technology, CT perfusion imaging is playing an increasingly important role in the diagnosis and treatment of the disease. CT perfusion imaging which is one of the hot spots in the field of medical image processing is taken to reveal the physiological and pathological state of the organization by the cell level and the level of microcirculation. CT perfusion imaging applied in the head has become more sophisticated, but rather slow in the liver, because the liver has a the complex dual blood supply system. Compared with the head CT perfusion imaging, liver CT perfusion imaging is more difficult. The purpose of this paper is to develop a set of CAD software for CT liver perfusion. The software calculates the liver perfusion parameters, and generates functional images to improve the quality and efficiency of diagnosis of liver disease for the doctor. In this thesis, we finish these aspects of work: First of all, we introduce the basic principles of the perfusion imaging, of the several perfusion mathematical model and perfusion imaging