活性聚合合成热敏性的凝胶.pdfVIP

馨 复旦 大学硕 士论 久 A b straet S y n th e s is o f T h e rm o s e n s itiv e G e l b y L iv in g P o ly m e riz a tio n A B S T R A C T Th erm o sen sitiv e g e l 15 a k in d o f P rom isin g m ateria ls for tissu e en g in eerin g ， m iero flu id ic s，an d d ru g d e liv ery ete . In g en era l，th e n etw o rk form atio n o eeu rs th lo u g h P h y siea lly in tera ctio n fro m se lf-a ssem b led su P ram o le eu lar strueture s o r eh em iea lly ero sslink fro m lab ile eo v a lent b o n d s.T h e P h y siea l ero sslink 15 form ed ty P iea lly th ro u g h n o n eo v a len t in teractio n s su eh a s h y d ro g en b o n d in g ，v an d er W aa ls in teraetio n s，Tt一Ttsta ck in g ，an d so lv oP h o b ie in terae tio n s ete .A lld eh em iea lly ero sslink u su a lly o rig in s from th e eo n e eP t o f d y n am ie eo v a len t eh em istry ，w h ieh ean o ffe r th e P o ssib ility o f “d o in g su P ram o leeu lar eh em istry ”at th e lev e l o f eo v a len t b o n d s b y in tro d u e in g d y n a m ie eo v a len t b o n d s in to th e P o ly m er u n its. In th is P ap er，th o u g h liv in g P o ly m erizatio n ，w e h av e su eeessfully sy n th esiz ed P eP tid e一b ase g els w h ieh are ero ss一link ed b y P h y siea l interaetion an d th e P o ly styren e g e ls w h ieh are ero ss一link ed b y d y n am ic eo v a len t b o n d s，an d w e h av e a lso in v e stig ated m eeh an ism o f th e g a latio n an d th e g e lb eh av io rs. 5 0 th is th esis 15 co n stitu te d o f p art s : F irstly ，W 己h av e su ee essfu lly synth e sized w e ll一d e fin ed b lo ck eo P o lyP eP tid e s， Poly [(丫一benzyl一