肿瘤的生物疗法英文综述.pdfVIP

ANTICANCER RESEARCH 32: 2229-2234 (2012) Review Biological Response Modifiers Used in Cancer Biotherapy 1 2 3 1 MASAHIDE KUROKI , SHINGO MIYAMOTO , TAKASHI MORISAKI , FUSANORI YOTSUMOTO , NAOTO SHIRASU 1, YOSHIE TANIGUCHI4 and GEN-ICHIRO SOMA5 Departments of 1Biochemistry and 2Obstetrics and Gynecology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan; 3Fukuoka Cancer General Clinic, Fukuoka, Japan; 4Department of Integrated and Holistic Immunology, Faculty of Medicine, Kagawa University, Miki-cho, Kagawa, Japan; 5Institute for Health Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima, Japan Abstract. Biotherapy is a form of treatment that uses the immunostimulant (3). BRMs used in biotherapy are usually natural immune system to protect the body against infection, categorized into two groups (4). The first group consists of cancer, and other diseases, and can fortify the body against specific BRMs, such as vaccines and monoclonal antibodies some side-effects of other treatments. Biotherapy employs (MAbs) that provide antigen-specific immune response or substances called biological response modifiers (BRMs), activity, and may exhibit a direct antitumor effect. The second which include vaccines, monoclonal antibodies, cytokines, group comprises of non-specific BRMs, such as cytokines and and adjuvants. BRMs are used alone or in combination with adjuvants, which augment or stimulate the immune system ea