我院2008_2012年抗感染药物应用及细菌耐药趋势分析_王小兵.pdfVIP

我院2008－2012年抗感染药物应用及细菌耐药趋势分析Δ ＊ 王小兵 （南京医科大学第一附属医院药学部，南京 210029） 中图分类号 R969.3；R978；R446.5 文献标志码 A 文章编号 1001-0408（2014）02-0129-03 DOI 10.6039/j.issn.1001-0408.2014.02.11 摘 要 目的：分析我院抗感染药物近5年的用药现状和耐药菌株耐药率发展趋势，为抗感染药物采购、供应和临床合理应用提 供参考。方法：采用我院2008－2012年购药信息，对抗感染药物品种、金额进行排序分析；计算用药频度（DDDs ）和绘制细菌耐药 趋势图。结果：5年来抗感染药物消耗呈上升趋势，DDDs 却逐年下降；细菌耐药率呈缓慢上升趋势，铜绿假单胞菌耐药率呈下降 趋势，肺炎克雷伯菌、大肠埃希菌耐药率呈先降后升趋势。结论：抗感染药物临床使用量大，同时近年细菌耐药率呈增长趋势。 2008年来由于国家对抗感染药物使用率采取控制措施，使得抗感染药物用量和DDDs 下降，促使临床抗感染药物DDDs 趋于合 理；然而细菌耐药率上升的结果并不随着DDDs 降低而降低，揭示细菌耐药率上升是由多种因素共同作用导致，其相关性机制应 当进一步深入研究。 关键词 药物利用；抗感染药物；耐药；用药频度；趋势 Analysis of the Utilization of Anti-infective Drugs and the Trend of Bacterial Drug Resistance in Our Hospi- tal during 2008－2012 WANG Xiao-bing （Dept. of Pharmacy ，The First Affiliated Hospital of Nanjing Medical University ，Nanjing 210029，China ） ABSTRACT OBJECTIVE ：To analyze the application and development trend of anti-infective drugs in our hospital in nearly 5 years ，and to provide reference for the purchase ，supply and rational use of anti-infective drugs based on the trends of drug-resis- tant strains samples. METHODS ：The type and amount of drugs were sorted and analyzed by adopting drug purchase information during 2008－2012. The situation and development trend of anti-infective drugs were analyzed by calculating DDDs and regional bacteria resistant rate. RESULTS ：The consumption of anti-infective drugs showed an up trend in recent 5 years ，while the DDDs of anti-infective drugs were decreased year by year. The resistance rate of bacteria was increased slowly. The resistant rate of Pseu- domonas aeruginosa showed a declining trend ，and Klebsiella pneumoniae and Escherichia coli feel first and rose at last. CONCLU- SIONS ：A large amount of anti-infective drugs have been used while the bacteria resistant rate shows a trend