波依定仿单(国外英文资料).docVIP

波依定说明书 The directions of the poiding [approving document] approved by the state [Chinese name] The non-lordipine reliever [product English] Felodipine Sustained Release Tablets [manufacturers] 【 efficacy 】 High blood pressure, angina. 【 chemical composition 】 The main ingredients and chemical names of the products: the main ingredients are non-lodipine; Chemical name: 2, 6-dimethyl-4 - (2, 3-dichlorobenzyl) - 1, 4-dihydro-3, 5-pyridine diformate. [pharmacological action] This product is a second hydrogen pyridine class calcium channel blockers, and his group of peace (or) other calcium channel blockers reversible competition second hydrogen pyridine binding sites, can block the vascular smooth muscle and the voltage dependence of the cultured rabbit atrial cells Ca2 + current, and interrupt the rat induced by K + portal vein contracture. In vitro studies have shown that the selective inhibition of the smooth muscle of the vasculature is stronger than the cardiomyocardial effect. Negative muscle function can be detected in vitro, but it is not observed in the whole animal. Non-lordipine can reduce blood pressure in peripheral vascular resistance, and the pharmacological action is associated with the dosage of the drug, with an increase in the reflexive heart rate. The reduction of nonlodipine was a dose-dependent effect, which was positively correlated with the concentration of blood. In the first week, there was an increase in reflexive heart rate, but the effect decreased over time. The long-term heart rate may increase by five to 10 times a minute, and beta-blockers can combat this effect. The p-r phase of the electrocardiogram was not affected by the use of either the flat or beta-blockers. Clinical studies and electrophysiological studies show that the use of non-lodipine alone or with beta-blockers has no significant effect on the transmission of the heart (p-r, p-q, and h-v). Non-lodipine antihypertensive therapy was associated with a significant re