迟发性运动障碍与SODVal9Ala多态性的关系及柴胡桃仁胶囊治疗其疗效观察.pdf

·700· 及柴胡桃仁胶囊治疗其疗效观察 苏健民1 谭云龙1 周东丰2 曹连元1 杨甫德1 邹义壮1 张向阳1 张培琰1 摘要 目的 探讨迟发性运动障碍(tardive dismutase， 的疗效。方法 应用异常不自主运动量表(abno吼aIinvoluntarymovement and 阳性和阴性症状量表(positivenegativesymptoms 率，并观察柴胡桃仁胶囊治疗TD患者36例12周的疗效。结果正常组、TD组和非TD组在SODVal9Ala 仁胶囊对CT杂合子疗效显著优于TT纯合子(PO．05)。结论柴胡桃仁胶囊能有效缓解TD症状，疗效 可能与SoD的基因型有关；9Ala可能是TD发生的保护因素。 关键词运动障碍；药源性；精神分裂症；超氧化物歧化酶；多态性 and betweenTardive the of DismutaseVal9Alaand ReIationship DyskinesiaPoIymorphismSuperoxide Efficacy ofChaihuTaoren onItSU al Capsules Jian—min，TANYun—Iong，ZHOU Dong—feng，etBioZo∥f口ZP蔓，曲缸￡秽 OOD96) RPsm，’c^Cg咒￡Br，Be巧i咒gH“iZo竹gg。c口咒H撕户i￡口Z，BP巧i靠g(J Abstract To the between ofChaihuTaoren objectiVeinVestigaterelationshipefficacy the and ofvaline—alaninemissensemutationof9th 1 dis— polymorphism codan(Val9Ala，T183C)ofsuperoxide withtardive ofTDwasassessedabnormal mutase(SOD)in dyskinesia(TD)．Methods patients Severity by moVement the wereratedthe and scale(AIMS)，and inVoluntary psychologicsymptoms by positivenegative of1 scale(PANSS)．Thesizeconsisted19 withTD totheTD symptoms sample patients assigned group，129 of chronic withthe conditionmatched withthatoftheenroUedTD patients schizophreniageneral strictly pa． tients tothenon—TD 148 tothenomal distribu— assigned group