生物化学I-英文版 Chapter 9 lipids membranes.pptVIP

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2017-05-16 发布于浙江
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生物化学I-英文版 Chapter 9 lipids membranes.ppt

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* Chapter 9 Lipids membranes * Fig 9.47 Activation of receptor tyrosine kinases by ligand-induced dimerization * Chapter 9 Lipids membranes * Fig 9.47 (continued) Phosphorylated dimer phosphorylates cellular target proteins * Chapter 9 Lipids membranes * Fig 9.47 (continued) Each domain catalyzes phosphorylation of its partner * Chapter 9 Lipids membranes * Fig 9.48 Insulin receptor and tyrosine kinase activity Insulin binds to 2 extracellular a-chains Transmembrane b-chains then autophosphorylate Tyrosine kinase domains then phosphorylate insulin-receptor substrates (IRSs) (which are proteins) * Chapter 9 Lipids membranes * Fig 9.49 Insulin-stimulated formation of PIP3 * Chapter 9 Lipids membranes * Summary * Chapter 9 Lipids membranes * Table 9.3 Characteristics of membrane transport * Chapter 9 Lipids membranes * A. Pores and Channels Pores and channels are transmembrane proteins with a central passage for ions and small molecules Solutes of appropriate size, charge, and molecular structure can diffuse down a concentration gradient Process requires no energy Rate may approach diffusion-controlled limit * Chapter 9 Lipids membranes * Fig 9.30 Membrane transport through a pore or channel Central passage allows molecules and ions of certain size, charge and geometry to transverse the membrane * Chapter 9 Lipids membranes * B. Passive Transport Passive transport (facilitated diffusion) does not require an energy source Protein binds solutes and transports them down a concentration gradient * Chapter 9 Lipids membranes * Types of passive transport systems Uniport - transporter carries only a single type of solute Some transporters carry out cotransport of two solutes, either in the same direction (symport) or in opposite directions (antiport) * Chapter 9 Lipids membranes * Fig 9.31 Types of passive and active transport(a) Uniport(b) Symport(c) Antiport * Chapter 9 Lipids membranes * Fig 9.32 Kinetics of passive transport Initia