壳聚糖絮凝对双黄连口服液制剂中有效成分的影响_邢妍美.pdfVIP

2010, 44( 5): 33~ 34 /, 33 邢妍美, 李成应, 黄 娟, 林 红, 郑 莉, 冉 蓉, 吴连勇 (, 250100) [] 2010- 01- 06 [] A [] 1002- 1280 ( 2010) 05- 0033- 02 [] R917 [ ] 选用正交试验筛选壳聚糖絮凝澄清 最佳条件, 以主要成分黄芩苷作为含量考察指 标, 研究了壳聚糖作为澄清剂对双黄连口服液中黄芩苷含量 影响, 并与醇沉法进行了对比结 果显示, 壳聚糖能使双黄连提取液得到良好 澄清效果, 主要成分黄芩苷损失较小, 优于醇沉法, 表明壳聚糖能作为良好 澄清剂代替醇沉法处理双黄连口服液 [] 壳聚糖; 澄清剂; 正交试验; 双黄连口服液 E ffects of Ch itosan on A ctive Con stituen t in Shuanghuanglian Koufuye X ING Yan- me,i L IC eng- ying, HUANG Juan, LIN Hong, ZHENG L,i RAN Rong, WU Lian- yong (Q ilu A n mi al H eal th P roduc ts Co. , L td, j inan 250100; Ch ina ) Abs tract: T e effects of c itosan as clarifying agent on S uang uanglian Koufuyew ere studed w it t e content of baicalin as a reference. T e optmi um cond itions w ere selected by ort ogonal expermi ent. Results s ow ed t at compared w it t e precip itatedmet od by alco o,l t e loss of baicalinw as comparatively lessw en using c itosan It suggested t at c itosan could be used to clarify t e extracts of S uang uanglian Koufuye. K ey w ord s: c itosan; clarifying agent; ort ogonal expermi en;t S uang uanglian Koufuye 200514, ; , , , ( C H NO ) , 85%, 6 11 4 n , , 1% 1%; , 1. 2 实验方法 , 1. 2. 1 黄芩苷的提取方法 [ 1] , 1 10, [ 2- 3] 1. 5 , ; 2 8, 1 , , 2, 10, ( 1), 1 60% 24 , , 1. 1 仪器与药品 pH , -