O-季铵化-N,N-双烷基壳聚糖混合单分子膜及自组装囊泡性质.pdfVIP

学兔兔 化 工 进 展 20 1 5年第34卷第5期 CHEMICAL INDUSTRY AND ENGINEERING PROGRESS ·1365· 磺化／0-季铵化 双烷基壳聚糖混合单分子膜及 自组装囊泡性质 毛扬帆，李明春，辛梅华 (华侨大学材料科学与工程学院，环境友好功能材料教育部工程中心，福建 厦门 361021) 摘要：制备了具有良好油溶性的O．磺化．^lⅣ-双十二烷基壳聚糖(HSDLCS)和O．季铵化-N,Ⅳ_双十二烷基壳聚糖 (QADLCS)，研究了HSDLCS／QADLCS混合单分子膜和自组装囊泡性质的关系。结果表明，混合单分子膜的 崩溃压 (46．14mN／m)和最大压缩模量 ( ． ～，98．85mN／m)较相应的单组分大；自组装形成球形囊泡的粒 径在200~400nm；以维生素B12为模型药物制备HsDLcs／QADLcs复合囊泡的载药量为0．1987mg／mg，包封 率为38．25％，药物平衡释放率为23．68％。静电作用使得混合单分子膜的凝聚性和抗形变能力更强，复合囊泡药 物通透性降低，结构更紧密。单分子膜的Cs． 1与其相应载药囊泡药物平衡释放率呈一定的线性关系 关键词：壳聚糖；磺化；季铵化；双烷基化；单分子膜；囊泡 中图分类号：O 636．1 文献标志码：A 文章编号：1000—6613(2015)05—1365—06 DoI：10．16085~．issn．1000—6613．2015．05．030 Mixed monolayers and self-assembly vesicles of 0-sulfonated-N,N- dilauryl chitosan／0-quaternized-N,N-dilauryl chitosan MA0 Yangfan，LIMingchun，XINMeihua (College ofMaterial Science and Engineering，Engineering Research Center ofEnvironment-Friendly Functional Materials，Ministry ofEducation，Huaqiao University，Xiamen 361021，Fujian，China) Abstract：0il。soluble O。sulfonated-N,N-dilauryl chitosan(HSDLCS)and O—quaternized-N．N-dilauryl chitosan(QADLCS)with similar substitution were synthesized．The properties of mixed monolayers and self-assembly vesicles of HSDLCS and QADLCS were studied．The mixed monolayers had larger collapse pressure(兀c)larger maximum compression modulus(cs． ax-1)and limited molecular area ex) compared with HSDLCS and QADLCS monolayers．Spherical self-assembly vesicles were formed in diameter 200--400nm．Using Vitamin B12 as mod