外用中药对兔创面表皮细胞生长因子的影响.PDFVIP

2004 3 17 3 China J Orthop T rauma, Mar. 2004, Vol. 17, No. 3 135 1 2 2 董黎强, 章明, 王维佳 ( 1 , 310005;2 ) :( EGF) : 85 3 3571115 , EGF : 357 , 2 EGF (P 0. 01) 2 5 EGF ,7 7 1115 3 EGF , 2 ( P 0. 05) : EGF , ; ; Effect of the external use of Chinese traditional medicine on EGF of rabbit wound DON G Liqiang, ZHA N G M ing , WA N G Weij ia. Dep artment of Orthopaedics, Xinh a H osp ital of Zhej iang Province ( Zhej iang Hangz ho , 310005, China) Abstract Objective: To investigate the relation bet een the effect of the external use of Chinese medicine on EGF of granulation tissue in rabbit ound and ound healing.Methods: Under the same condition, the ex perimental deep ound models of 85 rabbits ere created by surgical operation. The ounds ere divided into three groups:Yuchuang film group( Group M) ,Shengji Yupi ointment group( Group G) and Vaseline group ( Group F) .In different healing phrase, the EGF protein content in the granulation tissue of rabbit s ound as measured by radioimmune method.Results:In the 3rd, 5th and 7th days,the EGF protein contents in the ounds of Group M and Group G ere more than those in the ounds of Group F ( P 0. 01) . In the 5th day,the EGF contents in the ounds of Group M and Group G got to the top content during the hole heal ing, 2 days earlier than those in the ounds of Group F. In the 11th and 15th days, the EGF contents of the three groups ere all decreased.In every observing day,there as not obvious difference bet een Group M and Group G ( P 0. 05) .Conclusion: Yuchuang film and Shengji Yupi ointment can both accelerate ound heal ing through increasing the EGF protein contents of rabbit ounds in the early and middle phrase of ound healing. Key words Epidermal gro th factor; Drugs,Chinese herbal; Wound