喷他佐辛在混合痔术中临床应用观察2.docVIP

喷他佐辛超前镇痛在吻合器痔上粘膜环切术中的应用 汤国辉 伍洲颂 刘丽兵 邓秋林 邢佼涛 南华大学附属南华医院肛肠外科（湖南 衡阳 421002） 摘要 目的:探讨喷他佐辛超前镇痛对吻合器痔上粘膜环切术（PPH）镇痛效果的影响。方法：将100例行PPH的混合痔患者随机分为二组，治疗组术前10分钟予以喷他佐辛30mg肌注，对照组术前10分钟予以安慰剂生理盐水2ml肌注，二组患者均采用腰俞穴麻醉，评定术中牵拉反应的抑制效果，观察二组患者术后2、6、8h 时 VAS 评分及不良反应的情况。结果：治疗组术中牵拉反应明显低于对照组（P0.05), 治疗组各时点的 VAS 评分均低于对照组（P0.05)，不良反应如恶心呕吐、头晕两组比较差异无统计学意义（P0.05)。结论：喷他佐辛超前镇痛用于混合痔PPH手术，能安全有效抑制牵拉反应,镇痛效果确切，不良反应小，值得临床进一步推广。 关键词:喷他佐辛；超前镇痛；PPH术 Application of pentazocine Preemptive analgesia in PPH Tang Guo-hui, Zhou-Song Wu, Li-Bing Liu,Qiu-lin DENG ,Jiao-Tao Xing , Colorectal Surgery, the Affiliated Nanhua Hospital of the Nanhua University,Hengyang,,Hunan Province, China,421002 [Abstract] Objective: To explore the analgesic  HYPERLINK /effect/ \t _blank effect of Application of pentazocine with Yaoshu acupoints anesthesia in PPH. Methods: 100 patients performed PPH were randomly divided into experimental group and control group, with 50 patients in each group. About 10 minutes before the operation,Pentazocine 30mg Im in the experimental group.then aline 2ml Im in the control group .The two groups of the anaesthesia are Yaoyu acupoints.Before and after PPH were observed, and the pain, force reflection and adverse reactions of two groups were also observed.The VAS scores in the 2 ,6 and 8 hours after PPH were also observed. Results: The VAS scores of experimental group during the three times was lighter than that of control group and the effective rate of inhibiting force reflection was higher than that of control group .The adverse reaction rate was no better than that of control group . Conclusion: Pentazocine with Yaoyu acupoints anesthesia in PPH is safe and effective, the force reflection is slight and better than single Yaoyu.Pentazocine with Yaoyu acupoints anesthesia in PPH , thus it is worthy of application in clinic. [Key words] Pentazocine; Preemptive analgesia; Procedure for prolapse and hemorrhoids 喷他佐辛（pentazocine，PTZ）是一种新的阿片受体激动-拮抗药物，选择性地激动 κ 受体，具有良好的镇痛效应，且不良反应比吗啡少，已广泛用于术后镇痛，