对“淋病与淋球菌L型培养”一文的商榷x.docxVIP

网址： HYPERLINK  第  PAGE 3 页，共  NUMPAGES 3 页 调Qalexandrite激光对太田痣黑素细胞作用机制的研究 调Qalexandrite激光对太田痣黑素细胞作用机制的研究 中华皮肤科杂志 1999年第3期第32卷 论著 作者：卢　忠　陈军庞　王侠生　方丽华　焦　圣　黄　雯 单位：200040上海医科大学华山医院皮肤科 关键词：太田痣激光黑素细胞显微镜检查，电子 【摘要】目的　研究调QAlexandrite激光对太田痣黑素细胞的作用机制。方法　在激光照射前及照射后各个阶段，对4例患者分别进行11例次组织病理学观察和14例次透射电镜观察。结果　激光照射瞬间，真皮黑素细胞破坏，黑素小体空泡化，真皮中形成圆形空泡。表皮无明显损伤。照射后3个月至1年间，巨噬细胞吞噬并清除黑素小体和细胞残骸，真皮黑素细胞减少，无纤维组织增生。结论　调QAlexandrite激光能选择性地破坏真皮黑素细胞，提示能无创伤性治疗太田痣。 Effect of Q－switched Alexandrite Laser Irradiation on the Dermal Melanocytes in Nevus of Ota LU Zhong, CHENG Junpang, WANG Xiasheng,et al. Department of Dermatology, Huashan Hospital, Shanghai Medical University, Shanghai 200040 【 Abstract】 Objective To investigate the effect of Q?switched Alexandrite laser irradiation on the dermal melanocytes in nevus of Ota.Methods Multiple biopsies were taken in 4 patients with nevus of Ota before and after laser irradiation, altogether 11 biopsies for light microscopic examination and 14 biopsies for transmission electron microscopic examination. Results Immediately after laser irradiation, the dermal melanocytes were destroyed, the melanosomes were disrupted like vacuoles with the formation of intradermal round vacuoles; the epidermis, however, remained intact. Three months to 1 year after irradiation, the disrupted melanosomes and the cell debris were scavenged mainly by macrophages. Dermal melanocytes gradually decreased in number. No fibrosis was found.Conclusion The dermal melanocytes in nevus of Ota can be selectively destroyed by Q?switched Alexandrite laser, without any gross injury. 【 Key words】 Nevus of Ota Lasers Melanocytes Microscopy, electron 眼－上腭褐青色痣(又名太田痣)的主要病理变化是真皮中出现黑素细胞，以往各种治疗方法如磨削、冷冻、植皮、化学药物剥脱术等，均由表皮破坏至真皮而达到治疗目的，在临床上虽有一定疗效，但同时也损伤周围组织而导致瘢痕形成、色素异常等后遗症。近年来探索应用新型脉冲式激光治疗太田痣，希望达到既破坏真皮黑素细胞，而又不损伤周围组织的无创伤治疗效果。为此，我们对太田痣真皮黑素细胞在激光照射前后的组织病理和超微结构变化进行了研究，目的是掌握调QAlexandrite激光对太田痣真皮黑素细胞的作用机制，从而在临床上达到治疗太田痣的目的。现将观察结果报道如下。 材料和方法 1.调QAlexandr